微生物代谢物引导压力下的肠干细胞命运

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-05-02 DOI:10.1016/j.stem.2024.04.006

Shu Zhu, Wen Pan

引用次数: 0

摘要

最近，Wei 等人1 在《细胞新陈代谢》（Cell Metabolism）杂志上揭示了一条从大脑到肠道的通路，这条通路将心理压力传递给肠道上皮细胞，导致其功能障碍。这一肠道-大脑轴涉及一种微生物代谢物--吲哚-3-乙酸酯（IAA），它是一种利基信号，阻碍线粒体呼吸，从而改变肠道干细胞（ISC）的命运。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microbial metabolite steers intestinal stem cell fate under stress

Recently in Cell Metabolism, Wei et al.¹ unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.