揭开核 RNA 平衡的神秘面纱

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-05-02 DOI:10.1016/j.stem.2024.03.014

Lin Shan, Ling-Ling Chen

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引用次数: 0

摘要

核RNA稳态如何影响细胞功能仍是一个谜。在本期《细胞干细胞》（Cell Stem Cell）杂志上，Han等人1利用一种靶向EXOSC2的可控蛋白降解系统扰乱了小鼠多能胚胎干细胞中的RNA稳态，揭示了它在协调细胞健康的关键核事件中的重要作用。

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Unveiling the mystery of nuclear RNA homeostasis

How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.¹ utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.