肠道微生物群在 IgA 肾病发病机制中的作用

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY
Ellen F. Carney
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引用次数: 0

摘要

微生物组能调节免疫反应,对人类健康有重要影响,但它在获得性自身免疫性疾病中的潜在因果作用仍有待确定。现在,James Gleeson、Renato Monteiro及其同事报告了肠道微生物菌群失调可能导致IgA肾病(IgAN)发病机制的一种机制。由于肠壁腔侧的粘蛋白层含有与IgA1铰链区的O-连接糖相似的糖蛋白,研究人员调查了粘蛋白降解细菌是否能改变IgA1的糖基化。他们发现,粘蛋白降解菌(A. muciniphila)能在体外对人类 IgA1 进行糖基化。此外,在表达人类 IgA1 和 Fcα 受体 I 的小鼠(α1KI-CD89tg 小鼠)中,脱糖 IgA1 的数量与肠腔中不同部位粘蛋白噬菌体的相对丰度相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Role of the gut microbiota in the pathogenesis of IgA nephropathy

Role of the gut microbiota in the pathogenesis of IgA nephropathy
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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