肠肺轴与哮喘:机制历史回顾与未来展望

IF 4.6 2区 医学 Q2 ALLERGY
Xiu-Ling Song, Juan Liang, Shao-Zhu Lin, Yu-Wei Xie, Chuang-Hong Ke, Dang Ao, Jun Lu, Xue-Mei Chen, Ying-Zhi He, Xiao-Hua Liu, Wen Li
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引用次数: 0

摘要

背景 肠道微生物群与宿主免疫系统的发育和调节密切相关,它们调节免疫细胞的成熟和对病原体的抵抗力,从而影响宿主的免疫力。过早使用抗生素会破坏肠道微生物群的平衡,增加患哮喘的风险。肠道微生物群通过肠道-肺轴(肠道和肺之间的双向交流途径)与宿主免疫系统积极互动。通过益生菌、蠕虫疗法和粪便微生物群移植(FMT)来控制肠道微生物群以防治哮喘已成为一个热门研究课题。 正文 这篇综述主要介绍了当前哮喘的免疫发病机制、肠道微生物群以及肠道-肺轴在哮喘中的作用。此外,还讨论了操纵肠道微生物群及其代谢产物作为哮喘治疗策略的潜力。 结论 肠道-肺轴对哮喘有双向影响。肠道微生态失衡通过细菌结构成分和代谢产物导致哮喘。反过来,哮喘也会通过全身炎症造成肠道损伤。通过益生菌、蠕虫疗法和 FMT 来控制肠道微生物群,可以调节免疫细胞的成熟和对病原体的抵抗力,从而为哮喘的治疗策略提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Gut-lung axis and asthma: A historical review on mechanism and future perspective

Gut-lung axis and asthma: A historical review on mechanism and future perspective

Background

Gut microbiota are closely related to the development and regulation of the host immune system by regulating the maturation of immune cells and the resistance to pathogens, which affects the host immunity. Early use of antibiotics disrupts the homeostasis of gut microbiota and increases the risk of asthma. Gut microbiota actively interact with the host immune system via the gut-lung axis, a bidirectional communication pathway between the gut and lung. The manipulation of gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma has become a hot research topic.

Body

This review mainly describes the current immune pathogenesis of asthma, gut microbiota and the role of the gut-lung axis in asthma. Moreover, the potential of manipulating the gut microbiota and its metabolites as a treatment strategy for asthma has been discussed.

Conclusion

The gut-lung axis has a bidirectional effect on asthma. Gut microecology imbalance contributes to asthma through bacterial structural components and metabolites. Asthma, in turn, can also cause intestinal damage through inflammation throughout the body. The manipulation of gut microbiota through probiotics, helminth therapy, and FMT can inform the treatment strategies for asthma by regulating the maturation of immune cells and the resistance to pathogens.

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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
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