组装木酚素和诺尔木酚素的酶的功能和机制

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-04-30 DOI:10.1016/j.cbpa.2024.102462

Richiro Ushimaru

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引用次数: 0

摘要

木酚素和诺尔木酚素分布于整个植物界，具有多种化学结构和生物特性，具有潜在的治疗用途。它们源自苯丙类生物合成途径，其特有的碳结构是通过独特的酶催化作用形成的，具有区域和立体选择性的 C-C 键形成过程。尽管对这些植物天然产物进行了广泛的研究，但它们的生物合成途径和酶机制仍然是个谜。本综述重点介绍了在阐明负责构建木脂素和诺脂素独特碳框架的生物合成酶的功能和机制方面取得的最新进展。

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Functions and mechanisms of enzymes assembling lignans and norlignans

Lignans and norlignans are distributed throughout the plant kingdom and exhibit diverse chemical structures and biological properties that offer potential for therapeutic use. Originating from the phenylpropanoid biosynthesis pathway, their characteristic carbon architectures are formed through unique enzyme catalysis, featuring regio- and stereoselective C–C bond forming processes. Despite extensive research on these plant natural products, their biosynthetic pathways, and enzyme mechanisms remain enigmatic. This review highlights recent advancements in elucidating the functions and mechanisms of the biosynthetic enzymes responsible for constructing the distinct carbon frameworks of lignans and norlignans.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.