烟酰胺核苷和紫檀芪抑制紫外线辐射引起的组织肿胀和免疫抑制

IF 2.5 4区 医学 Q2 DERMATOLOGY
Verena Isak, Shayan Azizi, Xi K. Zhou, Devina Mehta, Wanhong Ding, Zakir Bulmer, Daniella S. Aivazi, Ryan W. Dellinger, Richard D. Granstein
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引用次数: 0

摘要

背景环境紫外线辐射会对人体产生有害影响,包括晒伤和免疫紊乱。方法为了研究 UVB 辐射引起的炎症效应,小鼠被喂食标准饲料/水、饲料中含 0.04% 紫檀芪和饮用水中含 0.2% 尼古丁酰胺核苷的食物、仅含尼古丁酰胺核苷的食物或仅含紫檀芪的食物。4 周后,将小鼠暴露于 UVB 辐射(3500 J/m2),并评估 24/48 小时的耳肿胀情况。我们还询问了在两种模型中,每种制剂或其组合是否能抑制紫外线辐射对接触过敏的抑制作用。给小鼠喂食标准饮食/水或含有 0.08% 紫檀芪的饲料、含有 0.4% 烟酸核苷的水或两者,持续 4 周。低剂量:每组一半的小鼠每天将脱毛后的背部暴露于紫外线辐射(1700 J/m2),持续 4 天,另一半小鼠则接受模拟辐射。在最后一次照射后 4 小时,用二硝基氟苯对小鼠受照射的背部进行免疫,7 天后用二硝基氟苯对小鼠的耳朵进行挑战,并评估 24 小时的耳朵肿胀情况。高剂量:结果烟酰胺核糖甙和紫檀芪共同抑制 UVB 引起的皮肤肿胀的效果优于单独使用其中一种。结论烟酰胺核苷和紫檀芪对紫外线辐射引起的组织肿胀和免疫抑制具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibition of UVB radiation‐induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene
BackgroundEnvironmental ultraviolet radiation has deleterious effects on humans, including sunburn and immune perturbations. These immune changes are involved in skin carcinogenesis.ObjectivesTo determine whether nicotinamide riboside and/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid‐range ultraviolet radiation.MethodsTo examine UVB radiation‐induced inflammatory effects, mice were fed standard chow/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4 weeks, mice were exposed to UVB radiation (3500 J/m2), and 24‐/48‐h ear swelling was assessed. We also asked if each agent or the combination inhibits UVB radiation suppression of contact hypersensitivity in two models. Mice were fed standard diet/water or chow containing 0.08% pterostilbene, water with 0.4% nicotinamide riboside, or both for 4 weeks. Low‐dose: Half the mice in each group were exposed on the depilated dorsum to UVB radiation (1700 J/m2) daily for 4 days, whereas half were mock‐irradiated. Mice were immunized on the exposed dorsum to dinitrofluorobenzene 4 h after the last irradiation, challenged 7 days later on the ears with dinitrofluorobenzene, and 24‐h ear swelling assessed. High dose: Mice were treated similarly except that a single dose of 10,000 J/m2 of radiation was administered and immunization was performed on the unirradiated shaved abdomen 3 days later.ResultsNicotinamide riboside and pterostilbene together inhibited UVB‐induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB‐induced immune suppression in both the low‐dose and high‐dose models while nicotinamide riboside alone was more effective in the low‐dose model than the high‐dose model.ConclusionNicotinamide riboside and pterostilbene have protective effects against UVB radiation‐induced tissue swelling and immune suppression.
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来源期刊
CiteScore
4.40
自引率
7.70%
发文量
85
审稿时长
6-12 weeks
期刊介绍: The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.
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