基于 RNN 和 GRU 的多核学习融合算法用于 ASD 诊断和致病脑区提取

IF 3.9 2区 生物学 Q1 MATHEMATICAL & COMPUTATIONAL BIOLOGY
Jie Chen, Huilian Zhang, Quan Zou, Bo Liao, Xia-an Bi
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引用次数: 0

摘要

自闭症谱系障碍(ASD)是一种与大脑发育有关的复杂而严重的疾病。它损害患者的语言交流和社会行为。近年来,自闭症研究主要集中在单模态神经影像数据上,忽视了多模态数据之间的互补性。这种疏忽可能会导致分类效果不佳。因此,研究 ASD 的多模态数据对于揭示其发病机制非常重要。此外,循环神经网络(RNN)和门控循环单元(GRU)在序列数据处理方面也很有效。本文介绍了一种基于 RNN 和 GRU 的多核学习融合算法(MKLF-RAG)的新型框架。该框架利用 RNN 和 GRU 为不同模态的数据提供特征选择。然后通过 MKLF 算法融合这些特征,检测 ASD 的病理机制,并提取与疾病最相关的感兴趣区(ROI)。本文提出的 MKLF-RAG 已在自闭症脑成像数据交换(ABIDE)数据库的各种实验中进行了测试。实验结果表明,我们的框架显著提高了自闭症分类的准确性。与其他方法相比,MKLF-RAG 在多个评估指标上都表现出卓越的功效,可为 ASD 的早期诊断提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multi-kernel Learning Fusion Algorithm Based on RNN and GRU for ASD Diagnosis and Pathogenic Brain Region Extraction

Multi-kernel Learning Fusion Algorithm Based on RNN and GRU for ASD Diagnosis and Pathogenic Brain Region Extraction

Autism spectrum disorder (ASD) is a complex, severe disorder related to brain development. It impairs patient language communication and social behaviors. In recent years, ASD researches have focused on a single-modal neuroimaging data, neglecting the complementarity between multi-modal data. This omission may lead to poor classification. Therefore, it is important to study multi-modal data of ASD for revealing its pathogenesis. Furthermore, recurrent neural network (RNN) and gated recurrent unit (GRU) are effective for sequence data processing. In this paper, we introduce a novel framework for a Multi-Kernel Learning Fusion algorithm based on RNN and GRU (MKLF-RAG). The framework utilizes RNN and GRU to provide feature selection for data of different modalities. Then these features are fused by MKLF algorithm to detect the pathological mechanisms of ASD and extract the most relevant the Regions of Interest (ROIs) for the disease. The MKLF-RAG proposed in this paper has been tested in a variety of experiments with the Autism Brain Imaging Data Exchange (ABIDE) database. Experimental findings indicate that our framework notably enhances the classification accuracy for ASD. Compared with other methods, MKLF-RAG demonstrates superior efficacy across multiple evaluation metrics and could provide valuable insights into the early diagnosis of ASD.

Graphical abstract

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来源期刊
Interdisciplinary Sciences: Computational Life Sciences
Interdisciplinary Sciences: Computational Life Sciences MATHEMATICAL & COMPUTATIONAL BIOLOGY-
CiteScore
8.60
自引率
4.20%
发文量
55
期刊介绍: Interdisciplinary Sciences--Computational Life Sciences aims to cover the most recent and outstanding developments in interdisciplinary areas of sciences, especially focusing on computational life sciences, an area that is enjoying rapid development at the forefront of scientific research and technology. The journal publishes original papers of significant general interest covering recent research and developments. Articles will be published rapidly by taking full advantage of internet technology for online submission and peer-reviewing of manuscripts, and then by publishing OnlineFirstTM through SpringerLink even before the issue is built or sent to the printer. The editorial board consists of many leading scientists with international reputation, among others, Luc Montagnier (UNESCO, France), Dennis Salahub (University of Calgary, Canada), Weitao Yang (Duke University, USA). Prof. Dongqing Wei at the Shanghai Jiatong University is appointed as the editor-in-chief; he made important contributions in bioinformatics and computational physics and is best known for his ground-breaking works on the theory of ferroelectric liquids. With the help from a team of associate editors and the editorial board, an international journal with sound reputation shall be created.
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