对法国三组疑似上肢横向缩窄缺损进行多学科结构性调查

IF 7.7 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Julie Boudet-Berquier, Christophe Demattei, Laurence Guldner, Anne Gallay, Sylvie Manouvrier, Jérémie Botton, Claire Philippat, Fleur Delva, Juliette Bloch, Caroline Semaille, Sylvie Odent, Isabelle Perthus, Hanitra Randrianaivo, Sylvie Babajko, Tiphaine Barjat, Claire Beneteau, Naima Brennetot, Ester Garne, Georges Haddad, Mounia Hocine, Isabelle Lacroix, Klervi Leuraud, Michel Mench, Joan Morris, Sophie Patrier, Arnaud Sartelet, Alain Verloes, Christophe Bonaldi, Mélina Le Barbier, Bertrand Gagnière, Philippe Pépin, Ronan Ollivier, Monique Bitoun, Lisa King, Andrea Guajardo-Villar, Eugenia Gomes, Jean-Claude Desenclos, Nolwenn Regnault, Alexandra Benachi
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引用次数: 0

摘要

导言:2019-2021 年间,面对公众的关切,科学专家委员会(SEC)对法国三个行政区域的疑似上肢横向缩窄畸形(TULRD)病例群进行了重新分析,最初的调查并未发现这些病例存在任何风险。在此,我们与大家分享我们为管理在多个地区出现的同类先天性畸形可疑群而开发的全国性方法。方法:SEC 分析了 TURLD 疑似病例的医疗记录,并对确诊病例进行了时空分析。如果病例群具有统计学意义且至少包括三个病例,SEC 就会审查从调查问卷、环境数据库和对病例住所附近农民进行的有关其使用植物产品情况的调查中获得的接触信息。结果:对病例进行重新确认后,在第一个行政区域内未发现具有统计学意义的群集。在第二个地区,确认了一个由四年内出生在附近两个城镇的四名儿童组成的病例群,但与最初的调查一样,没有发现任何已知的风险因素可以解释病例数超标的原因。在第三个地区,仅有两个同年出生在同一城镇的病例群得到确认。讨论情况:我们的经验表明,在一个国家的不同地区出现可疑病例群时,应优先选择协调和标准化的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France

Introduction: Between 2019–2021, facing public concern, a scientific expert committee (SEC) reanalysed suspected clusters of transverse upper limb reduction defects (TULRD) in three administrative areas in France, where initial investigations had not identified any risk exposure. We share here the national approach we developed for managing suspicious clusters of the same group of congenital anomalies occurring in several areas. Methods: The SEC analysed the medical records of TURLD suspected cases and performed spatiotemporal analyses on confirmed cases. If the cluster was statistically significant and included at least three cases, the SEC reviewed exposures obtained from questionnaires, environmental databases, and a survey among farmers living near to cases’ homes concerning their plant product use. Results: After case re-ascertainment, no statistically significant cluster was observed in the first administrative areas. In the second area, a cluster of four children born in two nearby towns over two years was confirmed, but as with the initial investigations, no exposure to a known risk factor explaining the number of cases in excess was identified. In the third area, a cluster including just two cases born the same year in the same town was confirmed. Discussion: Our experience highlights that in the event of suspicious clusters occurring in different areas of a country, a coordinated and standardised approach should be preferred.

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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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