{"title":"减少 LTBP2 的表达可抑制胶质瘤的增殖和迁移","authors":"Yonghui Zhang, Yue Qin, Xiaochen Yu","doi":"10.1007/s13273-024-00447-5","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Glioblastoma (GBM) is the most aggressive form of glioma. However, the treatment of GBM remains largely ineffective. LTBP2 is a secreted extracellular matrix protein involved in the progression of multiple tumors. However, the role and mechanism of LTBP2 in glioma remain unknown.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To uncover the possible effects of LTBP2 on the progression of gliomas and explore its underlying mechanism.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>LTBP2 was highly expressed in glioma. LTBP2 knockdown inhibited the growth of glioma cells. Downregulation of LTBP2 suppressed glioma cell motility. LTBP2 knockdown restrained the PI3K/AKT/mTOR pathway. LTBP2 knockdown suppressed glioma growth and migration and tumor growth in mice through the PI3K/AKT/mTOR axis.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>LTBP2 could serve as a potential therapeutic target for the treatment of gliomas.</p>","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"19 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Decreased LTBP2 expression inhibits proliferation and migration of glioma\",\"authors\":\"Yonghui Zhang, Yue Qin, Xiaochen Yu\",\"doi\":\"10.1007/s13273-024-00447-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Background</h3><p>Glioblastoma (GBM) is the most aggressive form of glioma. However, the treatment of GBM remains largely ineffective. LTBP2 is a secreted extracellular matrix protein involved in the progression of multiple tumors. However, the role and mechanism of LTBP2 in glioma remain unknown.</p><h3 data-test=\\\"abstract-sub-heading\\\">Objective</h3><p>To uncover the possible effects of LTBP2 on the progression of gliomas and explore its underlying mechanism.</p><h3 data-test=\\\"abstract-sub-heading\\\">Results</h3><p>LTBP2 was highly expressed in glioma. LTBP2 knockdown inhibited the growth of glioma cells. Downregulation of LTBP2 suppressed glioma cell motility. LTBP2 knockdown restrained the PI3K/AKT/mTOR pathway. LTBP2 knockdown suppressed glioma growth and migration and tumor growth in mice through the PI3K/AKT/mTOR axis.</p><h3 data-test=\\\"abstract-sub-heading\\\">Conclusion</h3><p>LTBP2 could serve as a potential therapeutic target for the treatment of gliomas.</p>\",\"PeriodicalId\":18683,\"journal\":{\"name\":\"Molecular & Cellular Toxicology\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-04-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & Cellular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13273-024-00447-5\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & Cellular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13273-024-00447-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Decreased LTBP2 expression inhibits proliferation and migration of glioma
Background
Glioblastoma (GBM) is the most aggressive form of glioma. However, the treatment of GBM remains largely ineffective. LTBP2 is a secreted extracellular matrix protein involved in the progression of multiple tumors. However, the role and mechanism of LTBP2 in glioma remain unknown.
Objective
To uncover the possible effects of LTBP2 on the progression of gliomas and explore its underlying mechanism.
Results
LTBP2 was highly expressed in glioma. LTBP2 knockdown inhibited the growth of glioma cells. Downregulation of LTBP2 suppressed glioma cell motility. LTBP2 knockdown restrained the PI3K/AKT/mTOR pathway. LTBP2 knockdown suppressed glioma growth and migration and tumor growth in mice through the PI3K/AKT/mTOR axis.
Conclusion
LTBP2 could serve as a potential therapeutic target for the treatment of gliomas.
期刊介绍：
Molecular & Cellular Toxicology publishes original research and reviews in all areas of the complex interaction between the cell´s genome (the sum of all genes within the chromosome), chemicals in the environment, and disease. Acceptable manuscripts are the ones that deal with some topics of environmental contaminants, including those that lie in the domains of analytical chemistry, biochemistry, pharmacology and toxicology with the aspects of molecular and cellular levels. Emphasis will be placed on toxic effects observed at relevant genomics and proteomics, which have direct impact on drug development, environment health, food safety, preventive medicine, and forensic medicine. The journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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