{"title":"保持生物酶稳定性的优化纳米级矿化策略","authors":"Yingying Li, Jiahao Li, Jialiang Li, Yuntian Yan, Yan Zhao, Weiheng Kong, Fengli Qu","doi":"10.1007/s10876-024-02624-x","DOIUrl":null,"url":null,"abstract":"<div><p>Conventional biomineralization strategies are constructed using microparticles, suffering the inhibition of protease bio-availability and required rigorous bio-evaluation. The use of nanomineralization technology could apply control over the size, shape, and composition of the materials and provide a steadier maintenance environment for the bio-enzyme. In this study, stable and nanoscale copper phosphate (Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>) bio-nanomineralization materials were constructed to encapsulate free bio-enzyme. By optimizing the biomineralization process, Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> was demonstrated to enable the facile coordination of various bio-enzymes (e.g., catalase or β-glucosidase) for efficient bio-enzyme transportation and maintaining the bio-enzyme activity in harsh condition. The current nanomineralization strategy could provide new ideas and methods for the development of biocatalysis, biosensing, biomedicine, and other related fields.</p></div>","PeriodicalId":618,"journal":{"name":"Journal of Cluster Science","volume":"35 6","pages":"1787 - 1796"},"PeriodicalIF":2.7000,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Optimized Nanoscale Mineralization Strategy for Maintaining Bio-enzymatic Stability\",\"authors\":\"Yingying Li, Jiahao Li, Jialiang Li, Yuntian Yan, Yan Zhao, Weiheng Kong, Fengli Qu\",\"doi\":\"10.1007/s10876-024-02624-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Conventional biomineralization strategies are constructed using microparticles, suffering the inhibition of protease bio-availability and required rigorous bio-evaluation. The use of nanomineralization technology could apply control over the size, shape, and composition of the materials and provide a steadier maintenance environment for the bio-enzyme. In this study, stable and nanoscale copper phosphate (Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>) bio-nanomineralization materials were constructed to encapsulate free bio-enzyme. By optimizing the biomineralization process, Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> was demonstrated to enable the facile coordination of various bio-enzymes (e.g., catalase or β-glucosidase) for efficient bio-enzyme transportation and maintaining the bio-enzyme activity in harsh condition. The current nanomineralization strategy could provide new ideas and methods for the development of biocatalysis, biosensing, biomedicine, and other related fields.</p></div>\",\"PeriodicalId\":618,\"journal\":{\"name\":\"Journal of Cluster Science\",\"volume\":\"35 6\",\"pages\":\"1787 - 1796\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cluster Science\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10876-024-02624-x\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cluster Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10876-024-02624-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Optimized Nanoscale Mineralization Strategy for Maintaining Bio-enzymatic Stability
Conventional biomineralization strategies are constructed using microparticles, suffering the inhibition of protease bio-availability and required rigorous bio-evaluation. The use of nanomineralization technology could apply control over the size, shape, and composition of the materials and provide a steadier maintenance environment for the bio-enzyme. In this study, stable and nanoscale copper phosphate (Cu3(PO4)2) bio-nanomineralization materials were constructed to encapsulate free bio-enzyme. By optimizing the biomineralization process, Cu3(PO4)2 was demonstrated to enable the facile coordination of various bio-enzymes (e.g., catalase or β-glucosidase) for efficient bio-enzyme transportation and maintaining the bio-enzyme activity in harsh condition. The current nanomineralization strategy could provide new ideas and methods for the development of biocatalysis, biosensing, biomedicine, and other related fields.
期刊介绍：
The journal publishes the following types of papers: (a) original and important research;
(b) authoritative comprehensive reviews or short overviews of topics of current
interest; (c) brief but urgent communications on new significant research; and (d)
commentaries intended to foster the exchange of innovative or provocative ideas, and
to encourage dialogue, amongst researchers working in different cluster
disciplines.
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