鱼皮移植与标准护理对慢性糖尿病足溃疡伤口愈合的影响：系统回顾和荟萃分析。

IF 2.6 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Primary Care Diabetes Pub Date : 2024-04-20 DOI:10.1016/j.pcd.2024.03.008

Maria Ruiz-Muñoz, Francisco-Javier Martinez-Barrios, Pablo Cervera-Garvi, Eva Lopezosa-Reca, Ana J. Marchena-Rodriguez

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引用次数: 0

摘要

导言本研究将探讨鱼皮移植（FSG）与标准护理（SOC）相比对糖尿病足溃疡愈合的效果。方法按照系统综述和荟萃分析首选报告项目（PRISMA）标准进行系统综述和荟萃分析。在 PubMed、EMBASE 和 Web of Science (WoS) 等电子数据库中搜索了溃疡完全愈合率。使用 Cochrane 协作组织推荐的工具进行了偏倚风险评估。统计分析包括研究的单项和综合结果、异质性检验、效应大小、敏感性分析和发表偏倚检验。荟萃分析表明，与对照组相比，接受鱼皮移植组的溃疡完全愈合率更高（OR = 3.34，95% CI 2.14-5.20，p < 0.01，I2 = 0%）。

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Fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: A systematic review and meta-analysis

Introduction

This study will explore the effectiveness of fish skin grafts (FSG) in ulcer healing in diabetic foot disease compared to standard of care (SOC).

Methods

The systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard. The electronic databases of PubMed, EMBASE, and Web of Science (WoS) internet were searched for the outcome rate of complete ulcer healing. The risk of bias assessment was conducted using the tool recommended by the Cochrane Collaboration. Statistical analysis included the individual and combined result of the studies, heterogeneity test, the effect size, sensitivity analysis, and publication bias tests.

Results

Five randomised controlled trials (RCTs) with a total of 411 patients were included in this study. This meta-analysis showed a higher rate of complete ulcer healing in groups receiving fish skin grafts (OR = 3.34, 95% CI 2.14–5.20, p < 0.01, I² = 0%) compared to control groups.

Conclusion

Fish skin grafts have been shown to be more effective for achieving complete ulcer healing compared to current conventional treatments in diabetic foot disease.

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来源期刊

Primary Care Diabetes ENDOCRINOLOGY & METABOLISM-PRIMARY HEALTH CARE

CiteScore

5.00

自引率

3.40%

发文量

134

审稿时长

47 days

期刊介绍： The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.