在格陵兰队列中探索 COVID-19 的动态:轻度急性病与长期 COVID 的中度风险

IF 1.5 Q4 INFECTIOUS DISEASES
Mie Møller , Trine Abelsen , Anna Irene Vedel Sørensen , Mikael Andersson , Lennart Friis Hansen , Christine Dilling-Hansen , Nikolai Kirkby , Peter Vedsted , Kåre Mølbak , Anders Koch
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引用次数: 0

摘要

本研究旨在探讨格陵兰岛居民如何经历急性和长期 COVID-19 的病程。方法 在对 310 名格陵兰成年人进行的调查中,我们通过在感染后 12 个月内重复进行三次问卷调查,评估了既往 SARS-CoV-2 感染与总体健康状况之间的关系,12 个月随访的回复率为 41%。研究对象包括 128 名 2022 年 1 月/2 月确诊感染 SARS-CoV-2 的患者和 182 名检测阴性的对照者。结果 在162名检测呈阳性的参与者中,共有53.7%的人在4周内康复,2.5%的人因感染SARS-CoV-2而住院治疗。最常见的症状是疲劳和轻度上呼吸道感染。只有不到 5%的受試者在感染後兩星期內請病假。与检测呈阴性的参与者相比,在检测呈阳性后的 12 个月内,报告疲劳(风险差异为 25.4%,95% 置信区间为 8.8-44.0)和精神疲惫(风险差异为 23.4%,95% 置信区间为 4.8-42.2)的风险增加。格陵兰人可能会感染长效 COVID,感染后症状可持续 12 个月。不过,在解释结果时,必须考虑到样本量小和响应率不高的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the dynamics of COVID-19 in a Greenlandic cohort: Mild acute illness and moderate risk of long COVID

Objectives

This study aimed to explore how the Greenlandic population experienced the course of both acute and long-term COVID-19. It was motivated by the unique epidemiologic situation in Greenland, with delayed community transmission of SARS-CoV-2 relative to the rest of the world.

Methods

In a survey among 310 Greenlandic adults, we assessed the association between previous SARS-CoV-2 infection and overall health outcomes by administering three repeated questionnaires over 12 months after infection, with a response rate of 41% at the 12-month follow-up. The study included 128 individuals with confirmed SARS-CoV-2 infection from January/February 2022 and 182 test-negative controls. Participants were recruited through personal approaches, phone calls, and social media platforms.

Results

A total of 53.7% of 162 participants who were test-positive recovered within 4 weeks and 2.5% were hospitalized due to SARS-CoV-2. The most common symptoms were fatigue and signs of mild upper respiratory tract infection. Less than 5% reported sick leave above 2 weeks after infection. Compared with participants who were test-negative, there was an increased risk of reporting fatigue (risk differences 25.4%, 95% confidence interval 8.8-44.0) and mental exhaustion (risk differences 23.4%, 95% confidence interval 4.8-42.2) up to 12 months after a positive test.

Conclusions

Our results indicate that during a period dominated by the Omicron variant, Greenlanders experienced a mild acute course of COVID-19, with quick recovery, minimizing the impact on sick leave. Long COVID may be present in Greenlanders, with symptoms persisting up to 12 months after infection. However, it is important to consider the small sample size and modest response rate as limitations when interpreting the results.

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IJID regions
IJID regions Infectious Diseases
CiteScore
1.60
自引率
0.00%
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审稿时长
64 days
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