亚急性接触黑磷量子点诱发心脏纤维化及肠道微生物群的潜在作用

IF 5.9 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Jianrong Han , Fengkai Ruan , Chunyan Yang , Zhenghong Zuo , Zonghong Liu , Chengyong He
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引用次数: 0

摘要

黑磷量子点(BPQDs)因其优异的电子导电性、光学和热电性能,已被用作生物医学领域的纳米载体。然而,目前仍缺乏对 BPQDs 安全性的评估,特别是 BPQDs 对心脏的影响和机制。本研究以特定的无病原体雄性小鼠为研究对象,连续 28 天口服不同剂量的 BPQDs(0.02、0.1、0.5 mg/kg)。暴露于 BPQDs 会降低心身比,导致心脏肥大和纤维化。此外,在心脏组织中还观察到了铁突变。最近的研究表明,口服 BPQDs 会改变肠道微生物群。在这里,无菌小鼠暴露于 0.1 毫克/千克的 BPQDs 28 天后,既没有出现心脏损伤,也没有出现铁变态反应。综上所述,该研究表明,BPQDs 可诱导心脏铁蛋白沉积和纤维化,这可能是由肠道微生物群介导的。这项研究有助于提高人们对 BP 纳米材料生物安全性的认识,促进纳米技术的可持续发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota

Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota

Black phosphorus quantum dots (BPQDs) have been used as the nano-carrier in the field of biomedicine due to their excellent electronic conductivity, optical and thermoelectric properties. However, it is still lack of evaluation of the safety of BPQDs, specifically on the effects and mechanisms of BPQDs on heart. In this study, the specific pathogen-free male mice were orally administered with different doses of BPQDs (0.02, 0.1, 0.5 mg/kg) for 28 days. BPQDs exposure decreased the heart-body ratio and caused cardiac hypertrophy and fibrosis. Additionally, ferroptosis was observed in the cardiac tissue. The recent study has shown BPQDs oral exposure alter gut microbiota. Here, after exposure to 0.1 mg/kg BPQDs for 28 days, the germ-free mice showed neither cardiac injury nor ferroptosis. Taken together, the study demonstrates that BPQDs induce cardiac ferroptosis and fibrosis, possibly mediated by gut microbiota. This research may aid in enhancing understanding of the biosafety of BP nanomaterials and promoting the sustainable development of nanotechnology.

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来源期刊
Journal of Environmental Sciences-china
Journal of Environmental Sciences-china 环境科学-环境科学
CiteScore
13.70
自引率
0.00%
发文量
6354
审稿时长
2.6 months
期刊介绍: The Journal of Environmental Sciences is an international journal started in 1989. The journal is devoted to publish original, peer-reviewed research papers on main aspects of environmental sciences, such as environmental chemistry, environmental biology, ecology, geosciences and environmental physics. Appropriate subjects include basic and applied research on atmospheric, terrestrial and aquatic environments, pollution control and abatement technology, conservation of natural resources, environmental health and toxicology. Announcements of international environmental science meetings and other recent information are also included.
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