{"title":"2% 利格诺卡因和 0.5% 布比卡因与 0.75% 罗哌卡因在 ASA 2 型白内障手术中作为眼周阻滞剂的效果比较","authors":"Sonal Gowaikar, Anusha Kumbhar, Sangita Patil","doi":"10.36106/ijar/9701058","DOIUrl":null,"url":null,"abstract":"Background: The most commonly accepted and used route of anaesthesia administration for cataract surgeries is the\nperibulbar route with a mixture of 2% lignocaine and 0.5% bupivacaine. It is a simple technique which produces the\ndesired anaesthetic, analgesic and akinetic effect on the eye. But both these anaesthetic agents are reported to produce cardiovascular and central\nnervous system side-effects. Safer agents like ropivacaine are being introduced into the clinical practice. Most of the patients undergoing\ncataract surgeries have associated comorbidities such as a hypertension, diabetes mellitus and asthma. Also, today's population is largely\naddicted to alcohol and smoking. Such patients are graded based on the American Society of Anaesthesiologists (ASA) grades prior to surgeries\nto assess their perioperative risks. This study focuses on comparing the characteristics of peribulbar blocks with 0.75% ropivacaine with the\npopularly used bupivacaine and lignocaine mixture and to assess their cardiotoxicity in ASA 2 patients. Methods: Eighty patients of ASA 2\ncategory with comparable demographic characteristics were allocated to two random groups of 40 each. Patients of groups A (lignocaine and\nbupivacaine) and B (ropivacaine) were given 8 ml mixture of 2% lignocaine (4 ml) + 0.5% bupivacaine (4ml) and 8 ml of 0.75% ropivacaine\neach and 100 IU of hyaluronidase respectively. Block characteristics like onset and duration of action and hemodynamic variables like systolic\nblood pressure, diastolic blood pressure and pulse rate were recorded, studied and analysed. Results: Duration of onset of the block in both the\ngroups was comparable but the total duration of the block and analgesia was found to be longer in group A than in group B. It was observed that\nthere were uctuations in the recorded values of blood pressure and pulse rate intraoperatively and postoperatively in Group A whereas these\nparameters were stable in Group B. Conclusion: Ropivacaine 0.75% in a volume of 8 ml with 100 IU of hyaluronidase is as effective as a 4:4\nmixture of bupivacaine 0.5% and lignocaine 2% in a volume of 8 ml with 100 IU of hyaluronidase with regards to onset of action. The total\nduration of the block and hemodynamic changes are less uctuating with the usage of ropivacaine indicating that ropivacaine is a safer drug for\ninduction of peribulbar anaesthesia in ASA 2 grade cataract patients.","PeriodicalId":13502,"journal":{"name":"Indian journal of applied research","volume":"56 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A COMPARISON OF THE EFFECTS OF 2% LIGNOCAINE AND 0.5% BUPIVACAINE WITH 0.75% ROPIVACAINE AS PERIBULBAR BLOCK FOR CATARACT SURGERIES IN ASA 2 PATIENTS\",\"authors\":\"Sonal Gowaikar, Anusha Kumbhar, Sangita Patil\",\"doi\":\"10.36106/ijar/9701058\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The most commonly accepted and used route of anaesthesia administration for cataract surgeries is the\\nperibulbar route with a mixture of 2% lignocaine and 0.5% bupivacaine. It is a simple technique which produces the\\ndesired anaesthetic, analgesic and akinetic effect on the eye. But both these anaesthetic agents are reported to produce cardiovascular and central\\nnervous system side-effects. Safer agents like ropivacaine are being introduced into the clinical practice. Most of the patients undergoing\\ncataract surgeries have associated comorbidities such as a hypertension, diabetes mellitus and asthma. Also, today's population is largely\\naddicted to alcohol and smoking. Such patients are graded based on the American Society of Anaesthesiologists (ASA) grades prior to surgeries\\nto assess their perioperative risks. This study focuses on comparing the characteristics of peribulbar blocks with 0.75% ropivacaine with the\\npopularly used bupivacaine and lignocaine mixture and to assess their cardiotoxicity in ASA 2 patients. Methods: Eighty patients of ASA 2\\ncategory with comparable demographic characteristics were allocated to two random groups of 40 each. Patients of groups A (lignocaine and\\nbupivacaine) and B (ropivacaine) were given 8 ml mixture of 2% lignocaine (4 ml) + 0.5% bupivacaine (4ml) and 8 ml of 0.75% ropivacaine\\neach and 100 IU of hyaluronidase respectively. Block characteristics like onset and duration of action and hemodynamic variables like systolic\\nblood pressure, diastolic blood pressure and pulse rate were recorded, studied and analysed. Results: Duration of onset of the block in both the\\ngroups was comparable but the total duration of the block and analgesia was found to be longer in group A than in group B. It was observed that\\nthere were uctuations in the recorded values of blood pressure and pulse rate intraoperatively and postoperatively in Group A whereas these\\nparameters were stable in Group B. Conclusion: Ropivacaine 0.75% in a volume of 8 ml with 100 IU of hyaluronidase is as effective as a 4:4\\nmixture of bupivacaine 0.5% and lignocaine 2% in a volume of 8 ml with 100 IU of hyaluronidase with regards to onset of action. The total\\nduration of the block and hemodynamic changes are less uctuating with the usage of ropivacaine indicating that ropivacaine is a safer drug for\\ninduction of peribulbar anaesthesia in ASA 2 grade cataract patients.\",\"PeriodicalId\":13502,\"journal\":{\"name\":\"Indian journal of applied research\",\"volume\":\"56 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian journal of applied research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.36106/ijar/9701058\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of applied research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.36106/ijar/9701058","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
背景:在白内障手术中,最普遍接受和使用的麻醉给药途径是使用 2% 木果碱和 0.5% 布比卡因混合物的周围麻醉途径。这是一种简单的技术,可对眼睛产生所需的麻醉、镇痛和刺激作用。但据报道,这两种麻醉剂都会对心血管和中枢神经系统产生副作用。罗哌卡因等更安全的麻醉剂正被引入临床实践。大多数接受白内障手术的患者都伴有高血压、糖尿病和哮喘等并发症。此外,如今的人群大多酗酒和吸烟。这类患者在手术前要根据美国麻醉医师协会(ASA)的等级进行分级,以评估他们的围手术期风险。本研究的重点是比较使用 0.75% 罗哌卡因与常用的布比卡因和木质素卡因混合物进行布巴周围阻滞的特点,并评估它们对 ASA 2 级患者的心脏毒性。方法:将具有相似人口统计学特征的 80 名 ASA 2 级患者随机分为两组,每组 40 人。给 A 组(木质素和布比卡因)和 B 组(罗哌卡因)患者分别注射 8 毫升 2% 木质素(4 毫升)+ 0.5% 布比卡因(4 毫升)和 8 毫升 0.75% 罗哌卡因混合物以及 100 IU 透明质酸酶。记录、研究和分析了阻滞特征(如起始时间和作用持续时间)和血液动力学变量(如收缩压、舒张压和脉搏)。结果:两组的阻滞起始时间相当,但 A 组的阻滞和镇痛总持续时间长于 B 组。据观察,A 组术中和术后的血压和脉搏记录值有 波动,而 B 组的这些参数保持稳定:就起效时间而言,将 0.75% 罗哌卡因与 100 IU 透明质酸酶按 4:4 的比例混合,将 0.5% 布比卡因和 2% 木质素卡因按 8 ml 的体积混合,再加入 100 IU 透明质酸酶,其效果与 0.75% 布比卡因和 2% 木质素卡因按 4:4 的比例混合,再加入 100 IU 透明质酸酶的效果相同。使用罗哌卡因后,阻滞的总持续时间和血流动力学变化的波动较小 ,这表明罗哌卡因是对 ASA 2 级白内障患者进行眼周麻醉的一种更安全的药物。
A COMPARISON OF THE EFFECTS OF 2% LIGNOCAINE AND 0.5% BUPIVACAINE WITH 0.75% ROPIVACAINE AS PERIBULBAR BLOCK FOR CATARACT SURGERIES IN ASA 2 PATIENTS
Background: The most commonly accepted and used route of anaesthesia administration for cataract surgeries is the
peribulbar route with a mixture of 2% lignocaine and 0.5% bupivacaine. It is a simple technique which produces the
desired anaesthetic, analgesic and akinetic effect on the eye. But both these anaesthetic agents are reported to produce cardiovascular and central
nervous system side-effects. Safer agents like ropivacaine are being introduced into the clinical practice. Most of the patients undergoing
cataract surgeries have associated comorbidities such as a hypertension, diabetes mellitus and asthma. Also, today's population is largely
addicted to alcohol and smoking. Such patients are graded based on the American Society of Anaesthesiologists (ASA) grades prior to surgeries
to assess their perioperative risks. This study focuses on comparing the characteristics of peribulbar blocks with 0.75% ropivacaine with the
popularly used bupivacaine and lignocaine mixture and to assess their cardiotoxicity in ASA 2 patients. Methods: Eighty patients of ASA 2
category with comparable demographic characteristics were allocated to two random groups of 40 each. Patients of groups A (lignocaine and
bupivacaine) and B (ropivacaine) were given 8 ml mixture of 2% lignocaine (4 ml) + 0.5% bupivacaine (4ml) and 8 ml of 0.75% ropivacaine
each and 100 IU of hyaluronidase respectively. Block characteristics like onset and duration of action and hemodynamic variables like systolic
blood pressure, diastolic blood pressure and pulse rate were recorded, studied and analysed. Results: Duration of onset of the block in both the
groups was comparable but the total duration of the block and analgesia was found to be longer in group A than in group B. It was observed that
there were uctuations in the recorded values of blood pressure and pulse rate intraoperatively and postoperatively in Group A whereas these
parameters were stable in Group B. Conclusion: Ropivacaine 0.75% in a volume of 8 ml with 100 IU of hyaluronidase is as effective as a 4:4
mixture of bupivacaine 0.5% and lignocaine 2% in a volume of 8 ml with 100 IU of hyaluronidase with regards to onset of action. The total
duration of the block and hemodynamic changes are less uctuating with the usage of ropivacaine indicating that ropivacaine is a safer drug for
induction of peribulbar anaesthesia in ASA 2 grade cataract patients.