利用自体富血小板血浆治疗盂关节病

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
K. Egiazaryan, MA Danilov, R. Abdusalamov
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引用次数: 0

摘要

注射富血小板血浆被认为是一种很有前景的治疗方法。作用于软骨下骨的药物可以改善组织结构,减缓关节软骨的破坏。本研究旨在分析关节内和骨内注射富血小板血浆(PRP)治疗骨关节病的效果。187 名参与者(强直性脊柱炎 1 至 3 期)被分为三组。第一组(治疗组)接受关节内 PRP 注射,第二组(对比组)接受骨内 PRP 注射。我们采用 SF-36 调查和视觉模拟量表进行评估。治疗三个月后,第一组和第二组最初的疼痛程度都有所减轻。在第一组中,滑膜炎的发病率在 3 个月后有所下降,在第二组中则在 6 个月后有所下降(分别为 21.9% 和 31.3%;P < 0.05)。治疗 6 个月后,第 1 组和第 2 组出现关节周围软组织肿胀的情况较少(分别为 8.2% 和 8.3%)。至于生活质量的身体部分,第 1 组在 3 个月后有所改善(70.40%),第 2 组在 6 个月后有所改善(69.80%);至于精神部分,第 1 组和第 2 组在治疗 3 个月后(分别为 64.30% 和 65.10%)以及治疗 6 个月后(分别为 65.10% 和 66.40%)的动态都得到了肯定。由此可见,在骨关节病病例中使用 PRP 可以减轻疼痛,提高生活质量。在缓解临床症状和改善患者生活质量方面,骨内注射 PRP 的效果明显更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment of gonarthrosis using autologous platelet-rich plasma
Injections of platelet-rich plasma are considered to be a promising treatment. Medicines acting on the subchondral bone can improve tissue's structure and slow down destruction of the articular cartilage. This study aimed to analyze the results of intraarticular and intraosseous administration of platelet-rich plasma (PRP) in gonarthrosis cases. One hundred and eighty-seven participants (gonarthrosis stages 1 through 3) were divided into three groups. Group 1 (treatment group) received intraarticular PRP injections, group 2 (comparison group) — intraosseous PRP injections. For assessment purposes, we used the SF-36 survey and visual analog scale. Three months after the treatment, initial pain level decreased in both groups 1 and 2. In group 1, the prevalence of synovitis went down after 3 months, in group 2 — after 6 months (21.9 and 31.3%, respectively; p < 0.05). Six months after the treatment, soft tissue swelling around the joint was registered less often in groups 1 and 2 (8.2 and 8.3%, respectively). As for the physical component of the quality of life, it improved in group 1 after 3 months (70.40%), in group 2 — after 6 months (69.80%); as for the mental component, the dynamics was acknowledged positive 3 months after the treatment in groups 1 and 2 (64.30 and 65.10%, respectively), and 6 months after the treatment (65.10 and 66.40%, respectively). Thus, administration of PRP in gonarthrosis cases attenuate pain and improves the quality of life. In terms of alleviation of the clinical symptoms and improvement of the physical component of patients' lives, intraosseous PRP injections performed significantly better.
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来源期刊
Bulletin of Russian State Medical University
Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-
CiteScore
0.80
自引率
0.00%
发文量
59
期刊介绍: Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.
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