L. T. Møllehave, Nils Jakob Knudsen, A. Linneberg, Inge Bülow Pedersen, G. Ravn-Haren, Anja Lykke Madsen, A. Carlé, Charlotte Cerqueira, A. Krejbjerg, L. B. Rasmussen, L. Ovesen, H. Perrild, Lena Bjergved Sigurd, B. Thuesen, Pernille Vejbjerg, T. Jørgensen
{"title":"丹麦碘摄入量与甲状腺疾病调查(DanThyr):历史与影响。","authors":"L. T. Møllehave, Nils Jakob Knudsen, A. Linneberg, Inge Bülow Pedersen, G. Ravn-Haren, Anja Lykke Madsen, A. Carlé, Charlotte Cerqueira, A. Krejbjerg, L. B. Rasmussen, L. Ovesen, H. Perrild, Lena Bjergved Sigurd, B. Thuesen, Pernille Vejbjerg, T. Jørgensen","doi":"10.1530/ETJ-23-0230","DOIUrl":null,"url":null,"abstract":"Due to mild to moderate iodine deficiency in Denmark, health authorities initiated a voluntary iodine fortification (IF) program in 1998, which became mandatory in 2000. In line with recommendations from WHO, the Danish Investigation on Iodine Intake and Thyroid Disease (DanThyr) was established to monitor the effect on thyroid health and diseases. The program involved different study designs and followed two Danish sub-populations in the years before IF and up till 20 years after. Results showed that the IF was successfully implemented and increased the level of iodine intake from mild-moderate iodine deficiency to low-adequacy. The level of thyroglobulin and thyroid volume decreased following IF and there was an indication of fewer thyroid nodules. The incidence of hyperthyroidism increased transiently following IF but subsequently decreased below the pre-fortification level. Conversely, thyroid stimulating hormone levels and the prevalence of thyroid autoimmunity increased along with an increase in the incidence of hypothyroidism. These trends were mirrored in the trends in treatments for thyroid disease. Most differences in thyroid health and disease between regions with different iodine intake levels before IF attenuated. This review illustrates the importance of a monitoring program to detect both beneficial and adverse effects and exemplifies how a monitoring program can be conducted when a nationwide health promotion program - as IF - is initiated.","PeriodicalId":12159,"journal":{"name":"European Thyroid Journal","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Danish Investigation on Iodine Intake and Thyroid Disease (DanThyr): history and implications.\",\"authors\":\"L. T. Møllehave, Nils Jakob Knudsen, A. Linneberg, Inge Bülow Pedersen, G. Ravn-Haren, Anja Lykke Madsen, A. Carlé, Charlotte Cerqueira, A. Krejbjerg, L. B. Rasmussen, L. Ovesen, H. Perrild, Lena Bjergved Sigurd, B. Thuesen, Pernille Vejbjerg, T. 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Conversely, thyroid stimulating hormone levels and the prevalence of thyroid autoimmunity increased along with an increase in the incidence of hypothyroidism. These trends were mirrored in the trends in treatments for thyroid disease. Most differences in thyroid health and disease between regions with different iodine intake levels before IF attenuated. This review illustrates the importance of a monitoring program to detect both beneficial and adverse effects and exemplifies how a monitoring program can be conducted when a nationwide health promotion program - as IF - is initiated.\",\"PeriodicalId\":12159,\"journal\":{\"name\":\"European Thyroid Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Thyroid Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1530/ETJ-23-0230\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Thyroid Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1530/ETJ-23-0230","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
The Danish Investigation on Iodine Intake and Thyroid Disease (DanThyr): history and implications.
Due to mild to moderate iodine deficiency in Denmark, health authorities initiated a voluntary iodine fortification (IF) program in 1998, which became mandatory in 2000. In line with recommendations from WHO, the Danish Investigation on Iodine Intake and Thyroid Disease (DanThyr) was established to monitor the effect on thyroid health and diseases. The program involved different study designs and followed two Danish sub-populations in the years before IF and up till 20 years after. Results showed that the IF was successfully implemented and increased the level of iodine intake from mild-moderate iodine deficiency to low-adequacy. The level of thyroglobulin and thyroid volume decreased following IF and there was an indication of fewer thyroid nodules. The incidence of hyperthyroidism increased transiently following IF but subsequently decreased below the pre-fortification level. Conversely, thyroid stimulating hormone levels and the prevalence of thyroid autoimmunity increased along with an increase in the incidence of hypothyroidism. These trends were mirrored in the trends in treatments for thyroid disease. Most differences in thyroid health and disease between regions with different iodine intake levels before IF attenuated. This review illustrates the importance of a monitoring program to detect both beneficial and adverse effects and exemplifies how a monitoring program can be conducted when a nationwide health promotion program - as IF - is initiated.
期刊介绍:
The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.