粪便微生物群移植在自身免疫性疾病中的应用--一篇关于病理疗法的详尽论文。

IF 9.2 1区 医学 Q1 IMMUNOLOGY
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引用次数: 0

摘要

感染在自身免疫性疾病发病机制中的作用早已得到认可和报道。几十年来,除了感染病原体外,"友好 "活菌(微生物组)的内部组成及其与免疫平衡和失调的相关性也引起了研究人员的关注。然而,直到最近才有科学论文提出将健康捐献者的微生物组转移到自身免疫性疾病患者体内的潜在作用。粪便微生物群移植(FMT)的逻辑是将负责免疫平衡的微生物从健康捐献者体内转移到免疫失调患者体内,对于我们的论文来说,更准确地说,是自身免疫性疾病患者体内。将微生物组视为病原体,我们就可以将 FMT 视为一种基于病原体的治疗方法。不同自身免疫性疾病的患者在接受 FMT 治疗后,都取得了良好的疗效。因此,在我们目前的广泛综述中,我们旨在强调 FMT 对各种自身免疫性疾病的影响,如炎症性肠病、自身免疫性甲状腺和肝病、系统性红斑狼疮和 1 型糖尿病等。据我们所知,在一篇论文中介绍 FMT 治疗 12 种以上自身免疫性疾病的所有方面,在医学文献中尚属首次。如此看待 FMT,确实有助于更好地理解和更新该模型在自身免疫性疾病治疗中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fecal microbiota transplantation in autoimmune diseases – An extensive paper on a pathogenetic therapy

The role of infections in the pathogenesis of autoimmune diseases has long been recognized and reported. In addition to infectious agents, the internal composition of the “friendly” living bacteria, (microbiome) and its correlation to immune balance and dysregulation have drawn the attention of researchers for decades. Nevertheless, only recently, scientific papers regarding the potential role of transferring microbiome from healthy donor subjects to patients with autoimmune diseases has been proposed. Fecal microbiota transplantation or FMT, carries the logic of transferring microorganisms responsible for immune balance from healthy donors to individuals with immune dysregulation or more accurately for our paper, autoimmune diseases. Viewing the microbiome as a pathogenetic player allows us to consider FMT as a pathogenetic-based treatment. Promising results alongside improved outcomes have been demonstrated in patients with different autoimmune diseases following FMT. Therefore, in our current extensive review, we aimed to highlight the implication of FMT in various autoimmune diseases, such as inflammatory bowel disease, autoimmune thyroid and liver diseases, systemic lupus erythematosus, and type 1 diabetes mellitus, among others. Presenting all the aspects of FMT in more than 12 autoimmune diseases in one paper, to the best of our knowledge, is the first time presented in medical literature. Viewing FMT as such could contribute to better understanding and newer application of the model in the therapy of autoimmune diseases, indeed.

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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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