绿色抗生物膜剂:微型综述

Shireen Adeeb Mujtaba Ali
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引用次数: 0

摘要

微生物生物lm 是由相似或不同种类的微生物协调组合而成的聚合物基质。与浮游生物相比,以生物lms 形式存在的细菌具有更强的抗药性,因此处理与生物lm 相关的院内感染和医疗器械感染非常困难。据报道,医疗保健领域每年用于应对生物lm 感染的支出约为 110 亿美元,但成功率却非常低。过去二十年对天然抗生物lm 试剂的研究表明,它们具有调节生物lm 的特性。因此,目前需要积极寻求无毒的天然抗生物lm 制剂。在这篇小型综述文章中,我们总结了绿色抗生物lm 制剂:抗菌肽(AMPs)、植物化学物、生物表面活性剂、纳米粒子和弱有机酸(WOA),并简要说明了它们的作用模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
GREEN ANTI-BIOFILM AGENTS: A MINI-REVIEW
Microbial biolm is the polymeric matrix formed by coordinated assembly of species of similar or different microorganisms. The bacteria in form of biolms are more resistant to drugs than compared to their planktonic counterparts, hence making it difcult to deal with biolm-associated nosocomial and medical device infections. Around $11 billion is annual expenditure reported to be employed in healthcare to deal with biolm infections but the success rates are very low. Studies on natural anti-biolm agents from the last two decades notably demonstrated their biolm modulation properties. Therefore, present state of affairs demands active pursual for non-toxic natural anti-biolm agents. In this mini-review article, we summarize green anti-biolm agents: antimicrobial peptides (AMPs), phytochemicals, biosurfactants, nanoparticles, and weak organic acids (WOA) with a brief note on their mode of action.
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