膳食纤维摄入量与罹患晚期和侵袭性前列腺癌的风险：15 项前瞻性队列研究的汇总分析》。

IF 3.5 2区医学 Q2 NUTRITION & DIETETICS

Journal of the Academy of Nutrition and Dietetics Pub Date : 2025-01-01 DOI:10.1016/j.jand.2024.04.006

Elkhansa Sidahmed PhD , Stephen J. Freedland MD , Molin Wang PhD , Kana Wu MD, PhD , Demetrius Albanes MD , Matt Barnett MS , Piet A. van den Brandt PhD , Michael B. Cook PhD , Graham G. Giles PhD , Edward Giovannucci MD, ScD , Christopher A. Haiman ScD , Susanna C. Larsson PhD , Timothy J. Key DPhil , Erikka Loftfield PhD , Satu Männistö PhD , Marjorie L. McCullough ScD , Roger L. Milne PhD , Marian L. Neuhouser PhD , Elizabeth A. Platz ScD , Aurora Perez-Cornago PhD , Stephanie A. Smith-Warner PhD

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Dietary Fiber Intake and Risk of Advanced and Aggressive Forms of Prostate Cancer: A Pooled Analysis of 15 Prospective Cohort Studies

Background

Evidence of an association between dietary fiber intake and risk of advanced and aggressive forms of prostate cancer (PC) and PC mortality is limited.

Objective

The aim of this study was to examine associations between intakes of dietary fiber overall and by food source and risk of advanced and aggressive forms of PC.

Design

The study design was a pooled analysis of the primary data from 15 cohorts in 3 continents. Baseline dietary fiber intake was assessed using a validated food frequency questionnaire or diet history in each study.

Participants/setting

There were 842 149 men followed for up to 9 to 22 years between 1985 and 2009 across studies.

Main outcome measures

The primary outcome measures were advanced (stage T4, N1, or M1 or PC mortality), advanced restricted (excluded men with missing stage and those with localized PC who died of PC), and high-grade PC (Gleason score ≥8 or poorly differentiated/undifferentiated) and PC mortality.

Statistical analysis performed

Study-specific multivariable hazard ratios (MVHR) were calculated using Cox proportional hazards regression and pooled using random effects models.

Results

Intake of dietary fiber overall, from fruits, and from vegetables was not associated with risk of advanced (n = 4863), advanced restricted (n = 2978), or high-grade PC (n = 9673) or PC mortality (n = 3097). Dietary fiber intake from grains was inversely associated with advanced PC (comparing the highest vs lowest quintile, MVHR 0.84; 95% CI 0.76-0.93), advanced restricted PC (MVHR 0.85; 95% CI 0.74-0.97), and PC mortality (MVHR 0.78; 95% CI 0.68-0.89); statistically significant trends were noted for each of these associations (P ≤ .03), and a null association was observed for high-grade PC for the same comparison (MVHR 1.00; 95% CI 0.93-1.07). The comparable results were 1.06 (95% CI 1.01-1.10; P value, test for trend = .002) for localized PC (n = 35,199) and 1.05 (95% CI 0.99-1.11; P value, test for trend = .04) for low/intermediate grade PC (n = 34 366).

Conclusions

Weak nonsignificant associations were observed between total dietary fiber intake and risk of advanced forms of PC, high-grade PC, and PC mortality. High dietary fiber intake from grains was associated with a modestly lower risk of advanced forms of PC and PC mortality.

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来源期刊

Journal of the Academy of Nutrition and Dietetics NUTRITION & DIETETICS-

CiteScore

7.20

自引率

10.40%

发文量

649

审稿时长

68 days

期刊介绍： The Journal of the Academy of Nutrition and Dietetics is the premier source for the practice and science of food, nutrition, and dietetics. The monthly, peer-reviewed journal presents original articles prepared by scholars and practitioners and is the most widely read professional publication in the field. The Journal focuses on advancing professional knowledge across the range of research and practice issues such as: nutritional science, medical nutrition therapy, public health nutrition, food science and biotechnology, foodservice systems, leadership and management, and dietetics education.