Chloé Smith MD , Manoj M. Lalu MD, PhD , Darryl R. Davis MD
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Prior to the presentation, a number of participants were unfamiliar with postoperative AF and biological therapies. However, postpresentation and post–focus group activities resulted in enhanced understanding of the research, with high levels of comprehension reported by all participants. The level of acceptance of EV therapy tended to increase, with a majority expressing willingness to participate in clinical trials and accept the therapy. The focus groups identified and addressed common questions regarding the potential risks and side effects of EVs, their source, dosing, utility for patients with preexisting AF, and the risk of human immunodeficiency virus (HIV) contraction or allergic reactions.</p></div><div><h3>Conclusions</h3><p>The study highlights the importance of providing education, involving the patient's circle of care, and addressing patient concerns, to promote acceptance of therapies such as EV therapy for postoperative AF.</p></div><div><h3>Clinical Trial Registration</h3><p><span>NCT05032495</span><svg><path></path></svg>.</p></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2589790X24001720/pdfft?md5=0011c792af7514aaa0ff933653ee7f38&pid=1-s2.0-S2589790X24001720-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exploring Patient Viewpoints to Optimize Implementation of a Biological Therapy for Atrial Fibrillation Prevention\",\"authors\":\"Chloé Smith MD , Manoj M. 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Prior to the presentation, a number of participants were unfamiliar with postoperative AF and biological therapies. However, postpresentation and post–focus group activities resulted in enhanced understanding of the research, with high levels of comprehension reported by all participants. The level of acceptance of EV therapy tended to increase, with a majority expressing willingness to participate in clinical trials and accept the therapy. 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引用次数: 0
摘要
背景了解患者的观点可以促进新型疗法向临床转化。本研究通过让患者参与评估使用细胞外囊泡(EVs)作为生物疗法预防术后房颤(AF)的可接受性,从而深入了解他们的态度和信息需求。结果与心律正常的患者相比,术后房颤患者在重症监护室和医院的住院时间更长。在演讲之前,许多与会者对术后房颤和生物疗法并不熟悉。然而,演讲后和焦点小组活动后,与会者对研究有了更深入的了解,所有与会者都表示理解程度很高。参与者对 EV 疗法的接受程度趋于提高,大多数人表示愿意参加临床试验并接受该疗法。焦点小组确定并解决了有关 EV 潜在风险和副作用、其来源、剂量、对已有房颤的患者的效用以及感染人类免疫缺陷病毒 (HIV) 或过敏反应的风险等常见问题。
Exploring Patient Viewpoints to Optimize Implementation of a Biological Therapy for Atrial Fibrillation Prevention
Background
Embracing patient viewpoints can enhance the translation of novel therapeutics to clinical settings. This study evaluated the acceptability of using extracellular vesicles (EVs) as a biological therapy for preventing postoperative atrial fibrillation (AF), through engagement with patients, providing insights into their attitudes and information needs.
Methods
Patients participated in prerecorded presentations, virtual focus groups, and surveys to assess their perspectives on EV therapy and determine the factors influencing their acceptance of the intervention.
Results
Participants with postoperative AF experienced prolonged intensive care unit and hospital stays, compared to those of patients with normal heart rhythm. Prior to the presentation, a number of participants were unfamiliar with postoperative AF and biological therapies. However, postpresentation and post–focus group activities resulted in enhanced understanding of the research, with high levels of comprehension reported by all participants. The level of acceptance of EV therapy tended to increase, with a majority expressing willingness to participate in clinical trials and accept the therapy. The focus groups identified and addressed common questions regarding the potential risks and side effects of EVs, their source, dosing, utility for patients with preexisting AF, and the risk of human immunodeficiency virus (HIV) contraction or allergic reactions.
Conclusions
The study highlights the importance of providing education, involving the patient's circle of care, and addressing patient concerns, to promote acceptance of therapies such as EV therapy for postoperative AF.