Ali Ashkbari , Hossein-Ali Nikbakht , Saeid Amirkhanlou , Ghazaleh Elahi , Marjan Salahi , Sareh Ebrahimi , Saeed Golfiroozi , Seyed Ahmad Hosseini , Mousa Ghelichi-Ghojogh
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引用次数: 0
摘要
研究表明，斋月期间禁食会对多种生化指标的循环水平产生不同的影响。本研究旨在全面评估有关斋月禁食对慢性肾脏病患者血脂、尿酸和 HbA1c 影响的研究。本研究从三个数据库（PubMed、Scopus 和 Web of Science）中系统地搜索和收集了相关研究。经过筛选后，对所选文章的质量和偏倚风险进行了评估。研究的异质性采用 Cochrane 检验和 I² 统计量进行评估。如果存在异质性，则采用反方差法随机效应模型。所有分析均使用 STATA 软件 16 版进行。本研究纳入了四项观察性研究。荟萃分析的结果显示，胆固醇（加权平均差（WMD）：0.21，95% CI：-0.09-0.51（P值=：0.18））、低密度脂蛋白（WMD：0.06，95% CI：-0.24-0.36（P值：0.69））、甘油三酯（WMD：0.05，95% CI：-0.25-0.35（P值：0.73））没有显著增加。尿酸（WMD：-0.11，95% CI：-0.42-0.21（P 值：0.51））和 HbA1c（WMD：-0.22，95% CI：-0.79-0.36（P 值：0.46））均无显著下降。分析结果显示，斋月禁食后，慢性肾脏病患者的血脂、尿酸和 HbA1c 均无明显变化。
Impact of Ramadan fasting on lipid profile, uric acid, and HbA1c in CKD: A systematic review and meta-analysis
Studies have shown that fasting during Ramadan has different effects on circulating levels of several biochemical markers. This study aims to conduct a comprehensive evaluation of studies related to the effect of fasting in the holy month of Ramadan on lipid profile, uric acid, and HbA1c in CKD patients. Studies were systematically searched and collected from three databases (PubMed, Scopus, and Web of Science). After screening, the quality and risk of bias assessment of the selected articles were evaluated. Study heterogeneity was assessed using the Cochrane test and I² statistic. In case of any heterogeneity random effects model with the inverse-variance method was applied. All analyses were performed using STATA software version 16. Four observational studies were included in this study. The results of this meta-analysis were that cholesterol (Weighted mean differences (WMD):0.21 with 95% CI:-0.09–0.51 (P-value=:0.18)), LDL (WMD:0.06 with 95% CI −0.24–0.36 (P-value:0.69)), triglyceride (WMD:0.05 with 95% CI:-0.25–0.35 (P-value:0.73)) had not-significant increase. Uric acid (WMD: −0.11 with 95% CI: −0.42–0.21 (P-value:0.51)) and HbA1c (WMD: −0.22 with 95% CI: −0.79–0.36 (P-value: 0.46)) show a non-significant decrease. The results of the analyses did not report significant changes in the lipid profile, uric acid, and HbA1c in CKD patients after Ramadan fasting.
期刊介绍：
The journal publishes original research articles and high quality reviews in the fields of clinical care, diabetes education, nutrition, health services, psychosocial research and epidemiology and other areas as far as is relevant for diabetology in a primary-care setting. The purpose of the journal is to encourage interdisciplinary research and discussion between all those who are involved in primary diabetes care on an international level. The Journal also publishes news and articles concerning the policies and activities of Primary Care Diabetes Europe and reflects the society''s aim of improving the care for people with diabetes mellitus within the primary-care setting.
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