{"title":"辣椒素通过调节癌症标志改善化疗反应：综述其协同潜力","authors":"R.F. Costa , F.C. Cadoná","doi":"10.1016/j.hermed.2024.100882","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Cancer is a disease caused by genetic changes and disordered cell growth with high incidences over the years. Conventional treatments such as chemotherapy act on cells that are in constant cell division; however, frequently, they are not selective to cancer cells and can damage healthy cells. For this reason, side effects such as nausea, dizziness, hair loss, weight loss, and fatigue are reported by patients. Moreover, some cancers present resistance to chemotherapy treatment. Therefore, studies focusing on functional and natural products, especially those rich in bioactive compounds, such as capsaicin, could be used as chemotherapy adjuvant to improve treatment response and decrease side effects.</p></div><div><h3>Methods</h3><p>In this scenario, we conducted a review of 75 articles regarding the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation.</p></div><div><h3>Results</h3><p>In this scenario, we reviewed the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation. This natural bioactive molecule ameliorates the chemotherapy response by several cancer pathway regulations.</p></div><div><h3>Conclusions</h3><p>This review was able to show that capsaicin has a remarkable effect as an adjuvant to improve chemotherapy and reduce side effects.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"45 ","pages":"Article 100882"},"PeriodicalIF":2.2000,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential\",\"authors\":\"R.F. Costa , F.C. Cadoná\",\"doi\":\"10.1016/j.hermed.2024.100882\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Cancer is a disease caused by genetic changes and disordered cell growth with high incidences over the years. Conventional treatments such as chemotherapy act on cells that are in constant cell division; however, frequently, they are not selective to cancer cells and can damage healthy cells. For this reason, side effects such as nausea, dizziness, hair loss, weight loss, and fatigue are reported by patients. Moreover, some cancers present resistance to chemotherapy treatment. Therefore, studies focusing on functional and natural products, especially those rich in bioactive compounds, such as capsaicin, could be used as chemotherapy adjuvant to improve treatment response and decrease side effects.</p></div><div><h3>Methods</h3><p>In this scenario, we conducted a review of 75 articles regarding the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation.</p></div><div><h3>Results</h3><p>In this scenario, we reviewed the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation. This natural bioactive molecule ameliorates the chemotherapy response by several cancer pathway regulations.</p></div><div><h3>Conclusions</h3><p>This review was able to show that capsaicin has a remarkable effect as an adjuvant to improve chemotherapy and reduce side effects.</p></div>\",\"PeriodicalId\":56077,\"journal\":{\"name\":\"Journal of Herbal Medicine\",\"volume\":\"45 \",\"pages\":\"Article 100882\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-04-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Herbal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2210803324000393\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324000393","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Capsaicin Ameliorates Chemotherapy Response via Cancer Hallmarks Modulation: An Overview of its Synergic Potential
Introduction
Cancer is a disease caused by genetic changes and disordered cell growth with high incidences over the years. Conventional treatments such as chemotherapy act on cells that are in constant cell division; however, frequently, they are not selective to cancer cells and can damage healthy cells. For this reason, side effects such as nausea, dizziness, hair loss, weight loss, and fatigue are reported by patients. Moreover, some cancers present resistance to chemotherapy treatment. Therefore, studies focusing on functional and natural products, especially those rich in bioactive compounds, such as capsaicin, could be used as chemotherapy adjuvant to improve treatment response and decrease side effects.
Methods
In this scenario, we conducted a review of 75 articles regarding the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation.
Results
In this scenario, we reviewed the anticancer activity and chemotherapy response improvement of capsaicin via cancer hallmark modulation. This natural bioactive molecule ameliorates the chemotherapy response by several cancer pathway regulations.
Conclusions
This review was able to show that capsaicin has a remarkable effect as an adjuvant to improve chemotherapy and reduce side effects.
期刊介绍：
The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.
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