NFκB 信号通路参与子痫前期的病理生理过程

IF 2.4 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Geburtshilfe Und Frauenheilkunde Pub Date : 2024-04-01 DOI:10.1055/a-2273-6318

Yaxi Li, Qinying Zhu, Ruifen He, Junhong Du, Xue Qin, Yi Li, Xiaolei Liang, Jing Wang

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引用次数: 0

摘要

子痫前期（PE）发病率高，是导致产妇和胎儿死亡的主要原因，并影响母婴的长期预后。终止妊娠是目前治疗子痫前期的唯一有效方法，因此迫切需要对其发病机制进行研究，并开发新的治疗方法。NFκB 转录因子家族在炎症和先天性免疫中起着至关重要的作用。在这篇综述中，我们总结了 NFκB 在正常妊娠和子痫前期妊娠中的作用、NFκB 在现有治疗策略中的作用以及潜在的 NFκB 治疗策略。

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The NFκB Signaling Pathway Is Involved in the Pathophysiological Process of Preeclampsia

The high prevalence of preeclampsia (PE) is a major cause of maternal and fetal mortality and affects the long-term prognosis of both mother and baby. Termination of pregnancy is currently the only effective treatment for PE, so there is an urgent need for research into its pathogenesis and the development of new therapeutic approaches. The NFκB family of transcription factors has an essential role in inflammation and innate immunity. In this review, we summarize the role of NFκB in normal and preeclampsia pregnancies, the role of NFκB in existing treatment strategies, and potential NFκB treatment strategies.

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来源期刊

Geburtshilfe Und Frauenheilkunde 医学-妇产科学

CiteScore

2.50

自引率

22.20%

发文量

828

审稿时长

6-12 weeks

期刊介绍： Geburtshilfe und Frauenheilkunde (GebFra) addresses the whole field of obstetrics and gynecology and is concerned with research as much as with clinical practice. In its scientific section, it publishes original articles, reviews and case reports in all fields of the discipline, namely gynecological oncology, including oncology of the breast obstetrics and perinatal medicine, reproductive medicine, and urogynecology. GebFra invites the submission of original articles and review articles. In addition, the journal publishes guidelines, statements and recommendations in cooperation with the DGGG, SGGG, OEGGG and the Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF, Association of Scientific Medical Societies, www.awmf.org). Apart from the scientific section, Geburtshilfe und Frauenheilkunde has a news and views section that also includes discussions, book reviews and professional information. Letters to the editors are welcome. If a letter discusses an article that has been published in our journal, the corresponding author of the article will be informed and invited to comment on the letter. The comment will be published along with the letter.