软骨鸟苷酸环化酶-B 受体在颅面骨骼发育中的作用

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
Marina Kashiwagi , Shigeki Yamanaka , Keita Asai , Takuma Watanabe , Takehiro Watanabe , Mariko Yamamoto-Kawai , Kazumasa Nakao
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引用次数: 0

摘要

目的C型钠尿肽(CNP)是钠尿肽家族的一员,它是一种强效的软骨内骨生长因子,通过鸟苷酸环化酶B(GC-B)受体发挥其生物效应。我们曾证实 CNP 基因敲除(KO)小鼠表现出沿矢状面的中面部发育不良;然而,GC-B(CNP 的受体)对颌面部内软骨骨化的影响仍不清楚,CNP/GC-B 系统的机制也尚未阐明。结果GC-B-KO小鼠表现出矢状面中部发育不良、枕骨大孔狭窄和椎管狭窄。组织学检查显示,颅颌面骨骼发育的关键生长中心--椎枕骨突(SOS)的厚度减少。结论这项研究强调了 GC-B 受体在颅颌面形态中的重要作用,有助于我们了解面部形态异常、枕骨大孔狭窄和椎管狭窄的发病机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of the cartilage guanylyl cyclase-B receptor in craniofacial skeletal development

Objective

C-type natriuretic peptide (CNP), a member of the natriuretic peptide family, is a potent endochondral bone growth factor that exerts its biological effects via the guanylate cyclase B (GC-B) receptor. We previously demonstrated that CNP knockout (KO) mice exhibited midfacial hypoplasia along the sagittal plane; however, the effects of GC-B (the receptor for CNP) on endochondral ossification in the maxillofacial region remain unclear, and the mechanism of the CNP/GC-B system has not been elucidated.

Methods

We investigated the physiological significance of GC-B in the cartilage of the craniofacial region through analysis of cartilage-specific GC-B KO mice. Morphological assessments were performed at 12 weeks old, with histological analyses performed at 2 weeks old.

Results

GC-B-KO mice exhibited sagittal midfacial hypoplasia, foramen magnum stenosis, and spinal canal stenosis. Histological examination revealed reduced thickness in the spheno-occipital synchondrosis (SOS), a critical growth center in cranio-maxillofacial skeletal development. The hypertrophic zone of the SOS exhibited reduced thickness, accompanied by a reduction in cell count in this area.

Conclusions

This study highlights the essential role of GC-B receptors in craniofacial morphology contributing to our understanding of the mechanisms underlying facial morphological abnormalities, foramen magnum stenosis, and spinal canal stenosis.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
129
审稿时长
83 days
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