细胞多倍体在大鼠和人类肝硬化肝脏再生中的作用

IF 1 4区生物学 Q4 GENETICS & HEREDITY

Comparative Cytogenetics Pub Date : 2024-04-02 DOI:10.3897/compcytogen.18.121459

N. Bezborodkina, Vsevolod Y. Brodsky, B. N. Kudryavtsev

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引用次数: 0

摘要

摘要多倍体是指细胞具有多套二倍体染色体。多倍体有两种形式。其中一种是生成性多倍体，是生物体所有细胞的特征，而另一种形式只在某些体细胞组织出生后的某些阶段才会出现。全基因组复制在植物和动物的进化过程中发挥了特别重要的作用，而细胞（体细胞）多倍体在生物体中的作用在很大程度上仍不清楚。在这项工作中，我们研究了细胞多倍体对 Rattusnorvegicus（Berkenhout，1769 年）和 Homosapiens Linnaeus，1758 年肝脏正常生长和修复性生长的贡献。研究表明，在正常的产后发育过程中和病理过程中，多倍体都对肝脏质量的增加做出了重要贡献。

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The role of cellular polyploidy in the regeneration of the cirrhotic liver in rats and humans

Abstract Polyploidy is a condition in which a cell has multiple diploid sets of chromosomes. Two forms of polyploidy are known. One of them, generative polyploidy, is characteristic of all cells of the organism, while the other form develops only in some somatic tissues at certain stages of postnatal ontogenesis. Whole genome duplication has played a particularly important role in the evolution of plants and animals, while the role of cellular (somatic) polyploidy in organisms remains largely unclear. In this work we investigated the contribution of cellular polyploidy to the normal and the reparative liver growth of Rattusnorvegicus (Berkenhout, 1769) and Homosapiens Linnaeus, 1758. It is shown that polyploidy makes a significant contribution to the increase of the liver mass both in the course of normal postnatal development and during pathological process.

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来源期刊

Comparative Cytogenetics 生物-遗传学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Comparative Cytogenetics is a peer-reviewed, open-access, rapid online journal launched to accelerate research on all aspects of plant and animal cytogenetics, karyosystematics, and molecular systematics. All published papers can be freely copied, downloaded, printed and distributed at no charge for the reader. Authors are thus encouraged to post the pdf files of published papers on their homepages or elsewhere to expedite distribution. There is no charge for color.