摩洛哥 Rh/ABO 系统与 SARS Cov2 感染之间的相关性*

Sanaa Sabour Alaoui, Amine Bennouri, Hamide Farhane
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摘要

需要探讨 COVID-19、ABO 血型系统和恒河猴之间的关联,以便提出与 SARS CoV2 感染相关的机制模型。在摩洛哥不同地区进行了一项回顾性病例对照关联研究,研究对象为 n = 5039 人,其中包括 4268 名 COVID-19 患者和 771 名对照组。研究分析了 COVID-19 患者与对照组之间的 Rh/ABO 血型分布差异。分析了 ABO 血型、性别、恒河猴和 COVID-19 特征之间的关系。血型与 SARS CoV2 感染的相关性分析表明,B、O、AB 血型的个体之间的差异具有统计学意义,而 A 血型的个体之间的差异不具有统计学意义。此外,Rh+ 表型的患者不易受感染,因此后者被认为具有保护作用,但 Rh- 血型的患者更易受感染,因此他们是危险因素。血型与 COVID-19 患者的一些临床特征有关。A 型和 B 型抗原的存在会增加感染 COV2 严重急性呼吸系统综合症的风险。而抗 A 抗体和抗 B 抗体的存在则使 O 型血的人免受感染。Rh+ 表型的病人比 Rh 表型的病人更不容易受到感染,因此这些病人被认为具有保护作用,即红细胞中存在 D 抗原。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation Between the Rh/ABO System and Infection Due to SARS Cov2 in Morocco*
The association between COVID-19, ABO blood group system and Rhesus needs to be explored in order to suggest a model of the mechanism linked to SARS CoV2 infection. A retrospective case-control association study was performed on the different regions of Morocco and carried out on a population of size n = 5039 including a total of 4268 COVID-19 patients and 771 control groups. The differences in the Rh/ABO blood group distribution between COVID-19 patients and the control group were analyzed. The relationship between ABO blood type, sexes, Rhesus and COVID-19 characteristics was analyzed. The analyzes of association between the blood group and the infection related to SARS CoV2 showed a statistically significant difference in the individuals of groups B, O, AB) respectively, but not blood group A. In addition, patients with the Rh+ phenotype are less vulnerable to infection therefore the latter are considered to have a protective effect, however the Rh- categories are more vulnerable to infection so they are risk factors. Blood type was related to some clinical characteristics of patients with COVID-19. The presence of the A and B antigens increase the risk of infection with SARS COV2. While the presence of anti A and anti B antibodies makes group O protector against infection. Patients with the Rh+ phenotype are less vulnerable to infection than Rh-therefore these are considered to have a protective effect which is the presence of the D antigen in red blood cells.
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