潜伏弓形虫感染与自杀未遂之间的潜在关联:基于病例对照登记的研究。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Mahdi Fakhar, M. Montazeri, M. Nakhaei, M. Soleymani, Z. Zakariaei, Ali Abbasi, Eissa Solaymani
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引用次数: 0

摘要

弓形虫是一种无处不在的寄生原虫,可能是导致神经和精神疾病的重要原因。这项基于病例对照登记的研究旨在评估伊朗北部马赞达兰省伊朗国家弓形虫登记中心的企图吸毒自杀者和对照组中的弓形虫感染率和相关风险因素。研究人员通过问卷调查收集了受试者的基线数据,并为每个人采集了血样。血浆用于血清学分析,而水疱则用于分子分析。在 282 人(147 例自杀企图者和 135 例对照者)中,42.9% 的患者和 16.3% 的对照者抗弓形虫免疫球蛋白 G (IgG) 呈阳性,但所有参与者的淋球菌 DNA 和抗弓形虫免疫球蛋白 M 均呈阴性。这些发现表明,南澳大利亚人的潜伏弓形虫感染率明显高于健康人,这表明至少在研究地区,潜伏弓形虫病与南澳大利亚人之间存在潜在联系。要了解淋病双球菌与世界不同人群和地区自杀之间的潜在联系,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Association Between Latent Toxoplasma gondii Infection and Suicide Attempts: A Case-Control Registry-Based Study.
Toxoplasma gondii is a ubiquitous parasitic protozoan that may be an important cause of neurological and psychiatric diseases. The purpose of this case-control registry-based study was to evaluate the prevalence of T. gondii infection and related risk factors among subjects who attempted suicide by drug use and a control group at the Iranian National Registry Center for Toxoplasmosis in Mazandaran Province, northern Iran. Baseline data were collected from participants using a questionnaire, and a blood sample was taken from each individual. The plasma was prepared for serological analysis, whereas the buffy coat was used for molecular analysis. Out of 282 individuals (147 cases with suicide attempters [SA] and 135 controls), 42.9% of patients and 16.3% of control subjects were positive for anti-Toxoplasma immunoglobin G (IgG), but all participants were negative for T. gondii DNA and anti-Toxoplasma immunoglobin M. Based on multiple logistic regressions, IgG seropositivity in SA in the age group of 20-30 years was 3.22 times higher than that in the control group (p < 0.001). These findings suggest that latent T. gondii infection among SA is significantly higher than that in healthy individuals, indicating a potential association between latent toxoplasmosis and SA at least in the studied area. Further research is needed to shed light on the potential association between T. gondii and suicide among different populations and areas of the world.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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