Scheuermann's 疾病患者缺乏维生素 D 会增加不良后果

IF 1.8 Q2 ORTHOPEDICS
SICOT-J Pub Date : 2024-04-03 DOI:10.1051/sicotj/2024010
Shivan N. Chokshi, S. Mudiganty, Rutledge Carter Clement, William Accousti
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引用次数: 0

摘要

导言Scheuermann's 病是一种常见于儿童患者的脊柱后凸症。动物模型研究表明,该病与维生素 D 缺乏有关,但尚未对人类进行广泛研究。本研究分析了维生素 D 缺乏对 Scheuermann's 疾病患者不利结果的影响。研究方法利用 TriNetX 数据库进行回顾性分析。使用国际疾病分类第十次修订版(ICD-10)代码对美国 0-18 岁的 Scheuermann's 疾病患者进行识别,并将其分为诊断出缺乏维生素 D 和未诊断出缺乏维生素 D 的两类。根据患者的年龄、性别、民族血统、之前的纤维肌痛、焦虑症、肌炎和重度抑郁症诊断,对各组患者进行比较。统计分析旨在确定维生素 D 水平与疼痛、抑郁、自杀企图、急诊科就诊、住院以及脊柱或脊髓手术等不利结果之间的关联。结果:共发现 11277 名患者,其中 39% 同时诊断为脊柱侧弯。缺乏维生素 D 的患者出现疼痛(P < 0.0001)、抑郁(P < 0.0001)、自杀未遂(P = 0.0021)、急诊就诊(P = 0.0246)和住院(P < 0.0015)的几率更大。相反,缺乏维生素 D 的患者接受脊柱或脊髓手术的几率降低(P = 0.0009)。结论:维生素 D 缺乏与疼痛、抑郁、自杀未遂、急诊室就诊和住院风险升高有关。我们的分析突出表明,有必要开展更多研究,探讨维生素 D 对 Scheuermann's 病的影响。证据级别三级,预后性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D deficiency in Scheuermann’s disease is associated with increased adverse outcomes
Introduction: Scheuermann’s disease is a diagnosis of hyperkyphosis commonly encountered in pediatric patients. Studies in animal models suggest an association with vitamin D deficiency, however, extensive studies have not been performed in humans. This study analyzes the role of vitamin D deficiency on unfavorable results in patients with Scheuermann’s disease. Methods: The TriNetX database was utilized to perform a retrospective analysis. Patients in the United States aged 0–18 years with Scheuermann’s disease were identified using International Classification of Diseases, Tenth Revision (ICD-10) codes and categorized into those with and without a diagnosis of vitamin D deficiency. Comparison of patient groups depending on age, sex, ethnic origin, prior diagnosis of fibromyalgia, anxiety disorder, myositis, and major depressive disorder. Statistical analysis was conducted to identify the association between vitamin D levels and unfavorable results including pain, depression, suicide attempt, emergency department (ED) consult, hospitalization, and procedures on the spine or spinal cord. Results: In total, 11,277 patients were identified, 39% of whom had a concurrent diagnosis of scoliosis. A total of 1,024 (9.08%) were deficient in vitamin D. Patients with vitamin D deficiency had greater odds of pain (P < 0.0001), depression (P < 0.0001), suicide attempt (P = 0.0021), ED visits (P = 0.0246), and hospital admission (P < 0.0015). Conversely, patients with vitamin D deficiency had decreased odds of surgery on the spine or spinal cord (P = 0.0009). Conclusion: Vitamin D deficiency is associated with an elevated risk of pain, depression, suicide attempts, ED visits, and hospitalization. Our analysis highlights the need for more research to study the effect of vitamin D on Scheuermann’s disease. Level of evidence: Level III, Prognostic
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来源期刊
SICOT-J
SICOT-J ORTHOPEDICS-
CiteScore
3.20
自引率
12.50%
发文量
44
审稿时长
14 weeks
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