费拉纪念讲座:我们是如何到达这里的?一个实验室在辐射诱导基因领域的奥德赛。

IF 2.5 3区 医学 Q2 BIOLOGY
Arslon Humayun, Lorreta Yun-Tien Lin, Henghong Li, A. Fornace
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引用次数: 0

摘要

本综述将重点介绍有助于我们了解辐射损伤后转录反应及其范围的早期发现。在开发出现代方法来评估整体的全球转录组反应之前,哺乳动物细胞可能以类似细菌的方式对 DNA 损伤因子做出反应的观点并未被普遍接受。为了研究这种可能性,识别差异表达的低丰度转录本技术的发展大大促进了我们的认识,即紫外线辐射和随后的电离辐射等 DNA 损伤因子确实会产生强有力的转录反应。在这里,我们将重点介绍我们对辐射诱导基因的鉴定和特征描述,以及即使是早期的应激基因信号转导研究也是如何凸显辐射损伤转录反应的广泛范围的。此后,辐射损伤转录反应在维持基因组完整性方面的核心作用在许多过程中得到了强调,包括细胞周期检查点控制、p53 和其他关键因子的抗癌作用、细胞衰老和新陈代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
FAILLA MEMORIAL LECTUREHow We Got Here: One Laboratory's Odyssey in the Field of Radiation-Inducible Genes.
This review focuses on early discoveries that contributed to our understanding and the scope of transcriptional responses after radiation damage. Before the development of modern approaches to assess overall global transcriptomic responses, the idea that mammalian cells could respond to DNA-damaging agents in a manner analogous to bacteria was not generally accepted. To investigate this possibility, the development of technology to identify differentially expressed low-abundance transcripts substantially facilitated our appreciation that DNA damaging agents like UV radiation and subsequently ionizing radiation did in fact produce robust transcriptional responses. Here we focus on our identification and characterization of radiation-inducible genes, and how even early studies on stress gene signaling highlighted the broad scope of transcriptional responses to radiation damage. Since then, the central role of transcriptional responses to radiation injury in maintaining genome integrity has been highlighted in many processes, including cell cycle checkpoint control, resistance to cancer by p53 and other key factors, cell senescence, and metabolism.
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来源期刊
Radiation research
Radiation research 医学-核医学
CiteScore
5.10
自引率
8.80%
发文量
179
审稿时长
1 months
期刊介绍: Radiation Research publishes original articles dealing with radiation effects and related subjects in the areas of physics, chemistry, biology and medicine, including epidemiology and translational research. The term radiation is used in its broadest sense and includes specifically ionizing radiation and ultraviolet, visible and infrared light as well as microwaves, ultrasound and heat. Effects may be physical, chemical or biological. Related subjects include (but are not limited to) dosimetry methods and instrumentation, isotope techniques and studies with chemical agents contributing to the understanding of radiation effects.
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