Elise Beckers, Joost M. Riphagen, Maxime Van Egroo, David A Bennett, Heidi I.L. Jacobs
{"title":"阿尔茨海默病灶部病理变化的稀疏不对称性","authors":"Elise Beckers, Joost M. Riphagen, Maxime Van Egroo, David A Bennett, Heidi I.L. Jacobs","doi":"10.3233/JAD-231328","DOIUrl":null,"url":null,"abstract":" Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer's disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology. Asymmetry in LC neuronal density may signal advanced disease progression and should be considered in AD neuroimaging studies of LC neurodegeneration.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"64 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease.\",\"authors\":\"Elise Beckers, Joost M. Riphagen, Maxime Van Egroo, David A Bennett, Heidi I.L. Jacobs\",\"doi\":\"10.3233/JAD-231328\",\"DOIUrl\":null,\"url\":null,\"abstract\":\" Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer's disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology. Asymmetry in LC neuronal density may signal advanced disease progression and should be considered in AD neuroimaging studies of LC neurodegeneration.\",\"PeriodicalId\":219895,\"journal\":{\"name\":\"Journal of Alzheimer's disease : JAD\",\"volume\":\"64 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease : JAD\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3233/JAD-231328\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease : JAD","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/JAD-231328","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在阿尔茨海默病（AD）中可观察到神经元（locus coeruleus，LC）神经元的 Tau 累积和神经变性。我们在拉什记忆与衰老项目（Rush Memory and Aging Project）的 77 例尸检病例中研究了喙侧和尾侧 LC 的纠结和神经元密度是否具有非对称模式的特征。我们发现，在有和没有AD病变的个体中，纠结密度左右对等。然而，神经元密度，尤其是LC尾端-喙轴的神经元密度，在有AD病变的个体中是不对称的。LC神经元密度的不对称性可能预示着疾病的晚期进展，在对LC神经变性进行AD神经影像学研究时应加以考虑。
Sparse Asymmetry in Locus Coeruleus Pathology in Alzheimer's Disease.
Tau accumulation in and neurodegeneration of locus coeruleus (LC) neurons is observed in Alzheimer's disease (AD). We investigated whether tangle and neuronal density in the rostral and caudal LC is characterized by an asymmetric pattern in 77 autopsy cases of the Rush Memory and Aging Project. We found left-right equivalence for tangle density across individuals with and without AD pathology. However, neuronal density, particularly in the caudal-rostral axis of the LC, is asymmetric among individuals with AD pathology. Asymmetry in LC neuronal density may signal advanced disease progression and should be considered in AD neuroimaging studies of LC neurodegeneration.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
