{"title":"PET 成像对了解阿尔茨海默病全身皮质醇代谢的重要性。","authors":"Jason Bini","doi":"10.3233/JAD-231463","DOIUrl":null,"url":null,"abstract":"Excess cortisol is associated with more severe cognitive decline, Alzheimer's disease, and related dementia phenotypes. The intracellular enzyme 11β-HSD1 regenerates active cortisol from inactive cortisone. In this current issue, high regional brain occupancy of Xanamemtrademark, determined by [11C]TARACT PET imaging of 11β-HSD1, in cognitively normal individuals and mild cognitive impartment/Alzheimer's disease (AD) patients is presented. In the future, comprehensive kinetic modeling using arterial sampling for occupancy studies, and whole-body PET imaging of 11β-HSD1 enzyme levels, in combination with stable isotope studies of cortisol metabolism, can provide broad insight into enzyme levels and activity in AD and other relevant diseases.","PeriodicalId":219895,"journal":{"name":"Journal of Alzheimer's disease : JAD","volume":"103 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer's Disease.\",\"authors\":\"Jason Bini\",\"doi\":\"10.3233/JAD-231463\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Excess cortisol is associated with more severe cognitive decline, Alzheimer's disease, and related dementia phenotypes. The intracellular enzyme 11β-HSD1 regenerates active cortisol from inactive cortisone. In this current issue, high regional brain occupancy of Xanamemtrademark, determined by [11C]TARACT PET imaging of 11β-HSD1, in cognitively normal individuals and mild cognitive impartment/Alzheimer's disease (AD) patients is presented. In the future, comprehensive kinetic modeling using arterial sampling for occupancy studies, and whole-body PET imaging of 11β-HSD1 enzyme levels, in combination with stable isotope studies of cortisol metabolism, can provide broad insight into enzyme levels and activity in AD and other relevant diseases.\",\"PeriodicalId\":219895,\"journal\":{\"name\":\"Journal of Alzheimer's disease : JAD\",\"volume\":\"103 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's disease : JAD\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3233/JAD-231463\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's disease : JAD","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3233/JAD-231463","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
过多的皮质醇与更严重的认知能力下降、阿尔茨海默病和相关痴呆症表型有关。细胞内酶 11β-HSD1 能从非活性可的松中再生出活性皮质醇。本期研究介绍了认知能力正常的人和轻度认知障碍/阿尔茨海默病(AD)患者通过 11β-HSD1 的 [11C]TARACT PET 成像确定的 Xanamemtrademark 在大脑中的高区域占有率。未来,利用动脉取样进行占位研究的综合动力学建模,以及 11β-HSD1 酶水平的全身 PET 成像,结合皮质醇代谢的稳定同位素研究,可以为了解 AD 和其他相关疾病的酶水平和活性提供广泛的视角。
The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer's Disease.
Excess cortisol is associated with more severe cognitive decline, Alzheimer's disease, and related dementia phenotypes. The intracellular enzyme 11β-HSD1 regenerates active cortisol from inactive cortisone. In this current issue, high regional brain occupancy of Xanamemtrademark, determined by [11C]TARACT PET imaging of 11β-HSD1, in cognitively normal individuals and mild cognitive impartment/Alzheimer's disease (AD) patients is presented. In the future, comprehensive kinetic modeling using arterial sampling for occupancy studies, and whole-body PET imaging of 11β-HSD1 enzyme levels, in combination with stable isotope studies of cortisol metabolism, can provide broad insight into enzyme levels and activity in AD and other relevant diseases.