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引用次数: 0
摘要
过多的皮质醇与更严重的认知能力下降、阿尔茨海默病和相关痴呆症表型有关。细胞内酶 11β-HSD1 能从非活性可的松中再生出活性皮质醇。本期研究介绍了认知能力正常的人和轻度认知障碍/阿尔茨海默病（AD）患者通过 11β-HSD1 的 [11C]TARACT PET 成像确定的 Xanamemtrademark 在大脑中的高区域占有率。未来，利用动脉取样进行占位研究的综合动力学建模，以及 11β-HSD1 酶水平的全身 PET 成像，结合皮质醇代谢的稳定同位素研究，可以为了解 AD 和其他相关疾病的酶水平和活性提供广泛的视角。
The Importance of PET Imaging to Understanding Whole-Body Cortisol Metabolism in Alzheimer's Disease.
Excess cortisol is associated with more severe cognitive decline, Alzheimer's disease, and related dementia phenotypes. The intracellular enzyme 11β-HSD1 regenerates active cortisol from inactive cortisone. In this current issue, high regional brain occupancy of Xanamemtrademark, determined by [11C]TARACT PET imaging of 11β-HSD1, in cognitively normal individuals and mild cognitive impartment/Alzheimer's disease (AD) patients is presented. In the future, comprehensive kinetic modeling using arterial sampling for occupancy studies, and whole-body PET imaging of 11β-HSD1 enzyme levels, in combination with stable isotope studies of cortisol metabolism, can provide broad insight into enzyme levels and activity in AD and other relevant diseases.
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