Manula S. B. Rathnayake, Manuela A. Boos, Brooke L Farrugia, G. V. van Osch, Kathryn S Stok
{"title":"关节软骨、耳软骨、半月板软骨和鼻软骨中糖胺聚糖介导的相互作用。","authors":"Manula S. B. Rathnayake, Manuela A. Boos, Brooke L Farrugia, G. V. van Osch, Kathryn S Stok","doi":"10.1089/ten.TEB.2023.0346","DOIUrl":null,"url":null,"abstract":"Glycosaminoglycans (GAGs) are ubiquitous components in the cartilage extracellular matrix (ECM). Ultrastructural arrangement of ECM and GAG mediated interactions with collagen are known to govern the mechanics in articular cartilage, but these interactions are less clear in other cartilage types. Therefore, this article reviews the current literature on ultrastructure of articular, auricular, meniscal, and nasal septal cartilage, seeking insight into GAG mediated interactions influencing mechanics. Ultrastructural features of these cartilages are discussed to highlight differences between them. GAG mediated interactions are reviewed under two categories: interactions with chondrocytes and interactions with other fibrillar macromolecules of the ECM. Moreover, efforts to replicate GAG mediated interactions to improve mechanical integrity of tissue-engineered cartilage constructs are discussed. In conclusion, studies exploring cartilage specific GAGs are poorly represented in the literature, and the ultrastructure of nasal septal and auricular cartilage are less studied compared to articular and meniscal cartilages. Understanding the contribution of GAGs in cartilage mechanics at the ultrastructural level, and translating that knowledge to engineered cartilage will facilitate improvement of cartilage TE approaches.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"30 119","pages":""},"PeriodicalIF":8.3000,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glycosaminoglycan mediated interactions in articular, auricular, meniscal, and nasal cartilage.\",\"authors\":\"Manula S. B. Rathnayake, Manuela A. Boos, Brooke L Farrugia, G. V. van Osch, Kathryn S Stok\",\"doi\":\"10.1089/ten.TEB.2023.0346\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Glycosaminoglycans (GAGs) are ubiquitous components in the cartilage extracellular matrix (ECM). Ultrastructural arrangement of ECM and GAG mediated interactions with collagen are known to govern the mechanics in articular cartilage, but these interactions are less clear in other cartilage types. Therefore, this article reviews the current literature on ultrastructure of articular, auricular, meniscal, and nasal septal cartilage, seeking insight into GAG mediated interactions influencing mechanics. Ultrastructural features of these cartilages are discussed to highlight differences between them. GAG mediated interactions are reviewed under two categories: interactions with chondrocytes and interactions with other fibrillar macromolecules of the ECM. Moreover, efforts to replicate GAG mediated interactions to improve mechanical integrity of tissue-engineered cartilage constructs are discussed. In conclusion, studies exploring cartilage specific GAGs are poorly represented in the literature, and the ultrastructure of nasal septal and auricular cartilage are less studied compared to articular and meniscal cartilages. Understanding the contribution of GAGs in cartilage mechanics at the ultrastructural level, and translating that knowledge to engineered cartilage will facilitate improvement of cartilage TE approaches.\",\"PeriodicalId\":5,\"journal\":{\"name\":\"ACS Applied Materials & Interfaces\",\"volume\":\"30 119\",\"pages\":\"\"},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2024-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Materials & Interfaces\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1089/ten.TEB.2023.0346\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/ten.TEB.2023.0346","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Glycosaminoglycan mediated interactions in articular, auricular, meniscal, and nasal cartilage.
Glycosaminoglycans (GAGs) are ubiquitous components in the cartilage extracellular matrix (ECM). Ultrastructural arrangement of ECM and GAG mediated interactions with collagen are known to govern the mechanics in articular cartilage, but these interactions are less clear in other cartilage types. Therefore, this article reviews the current literature on ultrastructure of articular, auricular, meniscal, and nasal septal cartilage, seeking insight into GAG mediated interactions influencing mechanics. Ultrastructural features of these cartilages are discussed to highlight differences between them. GAG mediated interactions are reviewed under two categories: interactions with chondrocytes and interactions with other fibrillar macromolecules of the ECM. Moreover, efforts to replicate GAG mediated interactions to improve mechanical integrity of tissue-engineered cartilage constructs are discussed. In conclusion, studies exploring cartilage specific GAGs are poorly represented in the literature, and the ultrastructure of nasal septal and auricular cartilage are less studied compared to articular and meniscal cartilages. Understanding the contribution of GAGs in cartilage mechanics at the ultrastructural level, and translating that knowledge to engineered cartilage will facilitate improvement of cartilage TE approaches.
期刊介绍:
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.