下丘脑-视神经脊索胶质瘤与颅咽管瘤核磁共振成像结果的比较。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-13 DOI:10.1177/02841851241241527

Ahmet Kursat Karaman, Kerime Hatun Özgen, B. Korkmazer, Rauf Hamid, Hatice Kübra Yıldırım, R. Kemerdere, N. Çomunoğlu, N. Tanrıöver, S. Arslan, Osman Kizilkilic

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Various MRI features were retrospectively evaluated for each lesion: T2-weighted imaging and fluid attenuation inversion recovery hyperintensity, calcification, cystic change, T1-weighted (T1W) imaging hyperintensity of the cystic component, hemorrhage, involvement of sellar, suprasellar or other adjacent structures, lobulated appearance, presence of hydrocephalus, and contrast enhancement pattern. Apparent diffusion coefficient (ADC) values were also evaluated and compared.\n\n\nRESULTS\nAmong 38 patients included, 13 (34%) had HOCG and 25 (66%) had craniopharyngioma. Craniopharyngiomas had a significantly higher rate of cystic changes, calcification, and T1W imaging hyperintensity of the cystic component than HOCGs (P <0.05). Of HOCGs, 92% had chiasm involvement, 23% had optic nerve involvement, and 31% had brain stem involvement. On the other hand, chiasm involvement was observed in 8% of craniopharyngiomas, but none had optic nerve and/or brain stem involvement (P <0.05). 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引用次数: 0

摘要

背景磁共振成像（MRI）对下丘脑-视神经脊索胶质瘤（HOCGs）和颅咽管瘤的鉴别诊断相当具有挑战性。材料和方法纳入 2012 年至 2022 年期间组织病理学评估确诊为 HOCG 或颅咽管瘤的患者，并对其进行术前对比增强脑磁共振成像检查。对每个病灶的各种 MRI 特征进行回顾性评估：T2加权成像和液体衰减反转恢复高密度、钙化、囊性改变、T1加权（T1W）成像囊性成分高密度、出血、累及蝶窦、鞍上或其他邻近结构、分叶状外观、是否存在脑积水以及对比增强模式。结果在纳入的 38 名患者中，13 人（34%）患有 HOCG，25 人（66%）患有颅咽管瘤。颅咽管瘤出现囊性改变、钙化和囊性成分 T1W 成像高密度的比例明显高于 HOCG（P <0.05）。在 HOCGs 中，92% 的患者有椎管受累，23% 的患者有视神经受累，31% 的患者有脑干受累。另一方面，在8%的颅咽管瘤中观察到了脉管受累，但没有视神经和/或脑干受累（P＜0.05）。62%的HOCGs（8/13）呈弥漫均质强化，而80%的颅咽管瘤（20/25）呈弥漫异质强化模式。结论虽然某些神经影像学结果可能会重叠，但囊肿和钙化的存在、脑干和视路受累、不同的增强模式和 ADC 值等特征可能有助于 HOCG 和颅咽管瘤的鉴别诊断。

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Comparison of MRI findings of hypothalamic-optic chiasmatic gliomas and craniopharyngiomas.

BACKGROUND Differential diagnosis of hypothalamic-optic chiasmatic gliomas (HOCGs) and craniopharyngiomas on magnetic resonance imaging (MRI) can be quite challenging. PURPOSE To compare the MRI features of HOCGs and cranipharyngiomas. MATERIAL AND METHODS Patients diagnosed with HOCG or craniopharyngioma in histopathological evaluation between 2012 and 2022 and who underwent preoperative contrast-enhanced brain MRI were included. Various MRI features were retrospectively evaluated for each lesion: T2-weighted imaging and fluid attenuation inversion recovery hyperintensity, calcification, cystic change, T1-weighted (T1W) imaging hyperintensity of the cystic component, hemorrhage, involvement of sellar, suprasellar or other adjacent structures, lobulated appearance, presence of hydrocephalus, and contrast enhancement pattern. Apparent diffusion coefficient (ADC) values were also evaluated and compared. RESULTS Among 38 patients included, 13 (34%) had HOCG and 25 (66%) had craniopharyngioma. Craniopharyngiomas had a significantly higher rate of cystic changes, calcification, and T1W imaging hyperintensity of the cystic component than HOCGs (P <0.05). Of HOCGs, 92% had chiasm involvement, 23% had optic nerve involvement, and 31% had brain stem involvement. On the other hand, chiasm involvement was observed in 8% of craniopharyngiomas, but none had optic nerve and/or brain stem involvement (P <0.05). While 62% (8/13) of HOCGs had diffuse homogeneous enhancement, 80% (20/25) of craniopharyngiomas had a diffuse heterogeneous enhancement pattern. Mean ADC values were significantly higher in craniopharyngiomas compared to HOCGs (2.1 vs. 1.6 ×10-3mm2/s, P <0.05). CONCLUSION Although some neuroimaging findings may overlap, features such as presence of cyst and calcification, brain stem and optic pathway involvement, different enhancement patterns, and ADC values may be helpful in the differential diagnosis of HOCGs and craniopharyngiomas.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.