补充维生素 D 和 E 对预防早产新生儿支气管肺发育不良 (BPD) 的影响:系统回顾与元分析》。

IF 1.3 Q3 PEDIATRICS
Nazanin Farahbakhsh, Deepak Sharma, S. Fatahi, M. Fathi, K. Vakili, N. Deravi, Zohreh Tutunchian, Elahe Ahsan, Shirin Yaghoobpoor, Seyed Ahmad Tabatabaii
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引用次数: 0

摘要

背景支气管肺发育不良(BPD)的病因是多因素的。本研究旨在比较补充维生素 D 或 E 的早产新生儿与未补充维生素 D 或 E 的早产新生儿发生 BPD 的风险。方法:通过检索 PubMed、Scopus 和 Web of Science 数据库(截至 2022 年 12 月),为本系统综述进行文献检索。随机对照试验涉及为早产新生儿提供维生素 D 或 E 并检查 BPD 的发生情况。我们排除了非英语文章以及数据不相关和不充分的文章。我们使用 "批判性评估技能计划"(CASP)核对表来评估纳入研究的质量。我们使用 Egger 检验来评估纳入研究的偏倚风险。异质性也通过 Q 检验和 I2 进行了评估。我们采用随机效应模型进行分析。P 值小于 0.05 即为显著。本研究的所有统计分析均使用 STATA 14 进行。结果分析了三项关于维生素 D 在预防 BPD 中作用的合格研究。元分析表明,补充维生素 D 可显著降低早产儿患 BPD 的风险(RR = 0.357,95% CI:0.189-0.675,I2 = 0.0%;P = 0.002)。同样,为评估维生素 E 在预防早产儿猝死症中的作用,对三项符合条件的研究进行了分析。结论补充维生素 D 有助于预防早产儿 BPD。然而,关于维生素 E 在降低早产儿 BPD 发生率方面的作用,目前还没有足够的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Vitamin D and E Supplementation on Prevention of Bronchopulmonary Dysplasia (BPD) in Premature Neonates: A Systematic Review and Meta-Analysis.
BACKGROUND Bronchopulmonary Dysplasia (BPD) has a multifactorial etiology. Vitamin E and vitamin D play an important role in lung development and can potentially be beneficial in the prevention of BPD. OBJECTIVE The study aimed to compare the risk of BPD occurrence in preterm neonates supplemented with vitamin D or E versus those who did not get supplementation. METHODS The literature search was conducted for this systematic review by searching the PubMed, Scopus, and Web of Science databases up to December 2022. Randomized controlled trials involved administering vitamin D or E to preterm neonates and examining the occurrence of BPD. We excluded non-English articles, and articles with non-relevant and insufficient data. We used the Critical Appraisal Skills Programme (CASP) checklist to assess the quality of the included studies. We used Egger's test to evaluate the risk of bias among the included studies. Heterogeneity was also assessed through Q-test and I2. We applied the random effect model for analysis. A P-value less than 0.05 was considered as significant. All the statistical analysis in the current study was performed using STATA 14. The Relative Risk (RR) was calculated as the effect size with 95% Confidence Interval (CI). RESULTS Three eligible studies seeking the role of vitamin D in the prevention of BPD were analysed. Meta-analysis revealed that receiving vitamin D supplementation can significantly reduce the risk of BPD in preterm infants (RR = 0.357, 95% CI: 0.189-0.675, I2 = 0.0%; p = 0.002). Similarly, for assessing the role of Vitamin E in the prevention of BPD, three eligible studies were analysed. Vitamin E supplementation was not found to play a significant role in the reduction of BPD (RR = 0.659, 95%CI = 0.243-1.786, I2 = 38.7%; p = 0.412). CONCLUSION Vitamin D supplementation could be beneficial in preventing BPD in preterm infants. However, evidence is not enough regarding vitamin E's role in reducing the incidence of BPD in preterm infants.
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
66
期刊介绍: Current Pediatric Reviews publishes frontier reviews on all the latest advances in pediatric medicine. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in pediatric medicine.
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