miRNA 是肥胖症与癌症之间的联系纽带。

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-Coding RNA Pub Date : 2024-04-15 DOI:10.3390/ncrna10020024

Grecia Denisse González-Sánchez, A. J. Granados‐López, Y. López-Hernández, Mayra Judith García Robles, Jesús Adrián López

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引用次数: 0

摘要

肥胖与癌症是全球关注的问题。事实证明，肥胖可能会诱发某些类型癌症的发生或发展；然而，非编码 RNA 与癌症之间的联系尚未得到全面探讨。在本综述中，我们讨论了肥胖和某些癌症所涉及的 miRNAs 和 lncRNAs 的失调，揭示了这些病症如何通过 ncRNAs 的失调而相互加重。本文介绍了对 lncRNA 和 miRNA 相互作用的硅学研究。我们的研究发现，在肥胖症和癌症中，分别有 44 个 lncRNA 上调和 49 个 lncRNA 下调，其中 miR-375、miR-494-3p、miR-1908 和 miR-196 分别与 1、4、4 和 4 个 lncRNA 相互作用，这些 lncRNA 参与 PPARγ 细胞信号的调控。此外，研究还发现，miR-130 在肥胖症中下调，并报道它调节了 5 个控制 PPARγ 细胞信号传导的 lncRNA。同样，miR-128-3p 和 miR-143 在肥胖症和癌症中被下调，分别与 5 个和 4 个与 MAPK 细胞信号调节相关的 lncRNA 相互作用。miRNA和lncRNA表达之间的微妙平衡成为肥胖相关癌症发展的关键决定因素，使这些分子成为有前景的生物标志物。然而，要想通过 ncRNA 就肥胖与癌症的关系得出可靠的结论，还需要更多更深入的研究。

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miRNAs as Interconnectors between Obesity and Cancer.

Obesity and cancer are a concern of global interest. It is proven that obesity may trigger the development or progression of some types of cancer; however, the connection by non-coding RNAs has not been totally explored. In the present review, we discuss miRNAs and lncRNAs dysregulation involved in obesity and some cancers, shedding light on how these conditions may exacerbate one another through the dysregulation of ncRNAs. lncRNAs have been reported as regulating microRNAs. An in silico investigation of lncRNA and miRNA interplay is presented. Our investigation revealed 44 upregulated and 49 downregulated lncRNAs in obesity and cancer, respectively. miR-375, miR-494-3p, miR-1908, and miR-196 were found interacting with 1, 4, 4 and 4 lncRNAs, respectively, which are involved in PPARγ cell signaling regulation. Additionally, miR-130 was found to be downregulated in obesity and reported as modulating 5 lncRNAs controlling PPARγ cell signaling. Similarly, miR-128-3p and miR-143 were found to be downregulated in obesity and cancer, interacting with 5 and 4 lncRNAs, respectively, associated with MAPK cell signaling modulation. The delicate balance between miRNA and lncRNA expression emerges as a critical determinant in the development of obesity-associated cancers, presenting these molecules as promising biomarkers. However, additional and deeper studies are needed to reach solid conclusions about obesity and cancer connection by ncRNAs.

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来源期刊

Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

6.70

自引率

4.70%

发文量

审稿时长

10 weeks

期刊介绍： Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.