耐多药和广泛耐药大肠埃希菌O157:H7的泛耐秋水仙碱流行率

Rawaa Jawad, Zina Alshami, Haidar Jiham
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引用次数: 0

摘要

抗菌素耐药性是威胁人类健康的一个重要问题。随着耐秋水仙素细菌的出现,世界卫生组织和美国疾病控制与预防中心宣布全球进入紧急状态,这场令人震惊的灾难可以追溯到抗生素出现之前。肠杆菌科细菌在全球范围内增长,产生碳青霉烯酶,肯定会导致耐药性的出现,因此秋水仙素的用量也随之上升。这项横断面研究包括 140 份拭子样本和 200 份尿液样本,它们都是从卡尔巴拉伊玛目侯赛因医疗城的病人身上采集的。除了人工抗生素耐药性测试确认外,还使用全自动 VITEK 2 紧凑型系统确定了细菌分离物的鉴定和抗生素耐药性模式。分离出的细菌对替卡西林(94.4%)、甲氧苄啶/磺胺甲噁唑(91.1%)和哌拉西林(87.3%)高度耐药。相比之下,在已形成的多重耐药(MDR)菌株总数(46.4%)和广泛耐药(XDR)菌株总数(25.4%)中,可乐定的耐药率最低(4.2%)。抗菌药耐药性是当今人类面临的最大健康问题之一。在伊拉克,广泛耐药大肠埃希菌 O157:H7 中出现的可乐定耐药性(2.8%)可能会导致治疗失败,尤其是烧伤和尿毒症患者。当务之急是通过谨慎使用抗生素和严格的感染控制规程来降低抗生素耐药性的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of Colistin Pan Resistance among Multidrug-Resistant and Extensively Drug-Resistant Escherichia Coli O157:H7
Antimicrobial resistance is an important problem threatening human health. With the appearance of colistin-resistant bacteria, the World Health Organization and Centers for Disease Control and Prevention are declaring a global emergency and an alarming disaster that goes back to the time before antibiotics. The usage of colistin rises as a result of the global growth of Enterobacteriaceae, which produces carbapenemase and certainly causes the emergence of resistance to investigate the prevalence of colistin resistance among multidrug-resistant and extensively drug-resistant E. coli. The cross-sectional study included 140 swab samples and 200 urine samples that were collected from patients attending Al Imam Al Hussein Medical City in Karbala. The identification of bacterial isolates and the pattern of antibiotic resistance were determined using the fully automated VITEK 2 compact system in addition to the manual antibiotic resistance testing confirmation. The isolates were highly resistant to Ticarcillin (94.4%), Trimethoprim/ Sulfamethoxazole (91.1%) and Piperacillin (87.3%). In contrast, colistin had the lowest (4.2%) out of the total multi-drug resistant (MDR) strains that formed (46.4%) and the extensively-drug resistant (XDR) strains (25.4). Antimicrobial resistance is one of the biggest health problems facing people today. In Iraq, the appearance of colistin resistance (2.8%) among extensively drug-resistant Escherichia coli O157:H7 may lead to failure of treatment, especially among burn and UTI patients. It is urgently recommended to lower the occurrence of antibiotic resistance through cautious antibiotic usage and stringent infection control protocols, which are priorities.
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