缺乏 Frataxin 会改变新陈代谢，通过葡萄糖分解促进反应性小胶质细胞的生长

IF 3.3 2区生物学 Q1 BIOLOGY

Life Science Alliance Pub Date : 2024-04-17 DOI:10.26508/lsa.202402609

Francesca Sciarretta, Fabio Zaccaria, Andrea Ninni, Veronica Ceci, Riccardo Turchi, S. Apolloni, M. Milani, Ilaria Della Valle, Marta Tiberi, V. Chiurchiù, N. D’Ambrosi, S. Pedretti, N. Mitro, C. Volonté, S. Amadio, Katia Aquilano, Daniele Lettieri-Barbato

引用次数: 0

摘要

Frataxin消耗会引发反应性小胶质细胞，增加葡萄糖分解代谢。丁酸盐治疗可恢复免疫代谢平衡，从而提供潜在的神经保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism

Frataxin depletion triggers reactive microglia with increase glucose catabolism. Butyrate treatment reinstates immunometabolic balance, potentially offering neuroprotection.

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来源期刊

Life Science Alliance Agricultural and Biological Sciences-Plant Science

CiteScore

5.80

自引率

2.30%

发文量

241

审稿时长

10 weeks

期刊介绍： Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.