缺乏 Frataxin 会改变新陈代谢，通过葡萄糖分解促进反应性小胶质细胞的生长

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-04-17 DOI:10.26508/lsa.202402609

Francesca Sciarretta, Fabio Zaccaria, Andrea Ninni, Veronica Ceci, Riccardo Turchi, S. Apolloni, M. Milani, Ilaria Della Valle, Marta Tiberi, V. Chiurchiù, N. D’Ambrosi, S. Pedretti, N. Mitro, C. Volonté, S. Amadio, Katia Aquilano, Daniele Lettieri-Barbato

引用次数: 0

摘要

Frataxin消耗会引发反应性小胶质细胞，增加葡萄糖分解代谢。丁酸盐治疗可恢复免疫代谢平衡，从而提供潜在的神经保护。

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Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism

Frataxin depletion triggers reactive microglia with increase glucose catabolism. Butyrate treatment reinstates immunometabolic balance, potentially offering neuroprotection.

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico