骨肉瘤和尤文氏肉瘤化疗对青春期后女性和男性性腺毒性的系统性综述

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-17 DOI:10.1089/jayao.2023.0185

Susanna Weidlinger, Satu Graber, Irina Bratschi, Janna Pape, Attila Kollár, Tanya Karrer, Michael von Wolff

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引用次数: 0

摘要

化疗药物的性腺毒性数据对于更好地指导年轻女性和男性了解不孕不育的风险以及在癌症治疗前更好地指明生育保护措施至关重要。然而，最近尚未对骨癌的此类数据进行审查。因此，我们对 2000 年以来发表的论文进行了系统的文献检索。本研究是 FertiTOX® 项目的一部分，该项目旨在改善癌症疗法性腺毒性数据缺乏的问题，从而提供更准确的生育力保护咨询。该项目只纳入了未复发的女性和男性患者。性腺毒性疗法引起的疑似不孕症定义为抗苗勒氏管激素极低、促性腺激素浓度高、闭经、少经、无精或少精子症。各项研究的质量采用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale，NOS）进行评估。在 831 项研究中，共有 11 项被纳入审查范围。在10/190（5.1%，范围0%-66%）例女性骨肉瘤患者（6项研究）、24/46（52.2%，范围46%-100%）例男性骨肉瘤患者（3项研究）、18/138（13.0%，范围3%-18%）例女性尤文氏肉瘤患者（3项研究）和34/38（89.5%）例男性尤文氏肉瘤患者（1项研究）中发现了疑似不育症。无法计算与特定化疗相关的风险。在所有患者都接受过烷化剂化疗的尤文氏肉瘤中，疑似不育的风险往往更高。在纳入的 11 项研究中，有两项研究的 NOS 质量得分较高，而其余 9 项研究的质量得分较低，主要原因是缺乏参照组。已发表的数据过于有限，无法准确估计性腺毒性。不过，数据显示临床上存在不孕不育的风险，这支持在化疗前为患者提供有关生育保护措施的咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Systematic Review of the Gonadotoxicity of Osteosarcoma and Ewing's Sarcoma Chemotherapies in Postpubertal Females and Males.

Data on gonadotoxicity of chemotherapies are essential to better counsel young females and males about the risk of infertility and to better indicate fertility preservation measures before cancer therapies. However, such data have not recently been reviewed for bone cancer. Therefore, a systematic literature search was conducted considering papers published since 2000. This study is part of the FertiTOX® project, which aims to improve the lack of data regarding gonadotoxicity of cancer therapies to enable more accurate counseling regarding fertility preservation. Only relapse-free women and men were included. Gonadotoxic therapy-induced suspected infertility was defined as very low anti-mullerian hormone, high gonadotropin concentration, amenorrhea, oligomenorrhea, azoospermia, or oligozoospermia. The quality of the individual studies was assessed using the Newcastle-Ottawa Scale (NOS). In total, 11 out of 831 studies were included in the review. Suspected infertility was found in 10/190 (5.1%, range 0%-66%) of female patients with osteosarcoma (six studies), in 24/46 (52.2%, range 46%-100%) of male patients with osteosarcoma (three studies), in 18/138 (13.0%, range 3%-18%) of female patients with Ewing's sarcoma (three studies), and in 34/38 (89.5%) of male patients with Ewing's sarcoma (one study). A risk calculation in relation to specific chemotherapies was not possible. Risk of suspected infertility tends to be higher in Ewing's sarcoma in which all patients received chemotherapies with alkylating agents. Two of the 11 included studies received a high NOS quality score, whereas the remaining nine studies received a low quality score, mainly because of the lack of a comparator group. Published data are too limited for precise estimation of the gonadotoxicity. However, data indicate clinically relevant risk for infertility, supporting counseling patients before chemotherapy about fertility preservation measures.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.