子宫平滑肌瘤：概述。

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-04-19 DOI:10.1097/pap.0000000000000446

Andre Pinto

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引用次数: 0

摘要

子宫平滑肌瘤是一组异质性间叶肿瘤，具有多种组织学变异和不同的生物学行为。病理学分类（良性、恶性潜能不确定、恶性）依赖于对有丝分裂指数、坏死和细胞学不典型程度的评估，每种亚型的阈值不同。由于与其他间质肿瘤（包括低级别和高级别子宫内膜间质瘤、炎性肌纤维母细胞瘤和 PEComa）在形态上有重叠，因此可能需要进行免疫组化和其他辅助研究来确定一部分病例的诊断。分子诊断技术的最新进展完善了平滑肌瘤的分类，但大多数病例的诊断纯粹是基于组织学依据。

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Uterine Smooth Muscle Tumors: An Overview.

Uterine smooth muscle tumors are a heterogeneous group of mesenchymal neoplasms with multiple histologic variants and distinct biological behaviors. Pathologic classification (benign, uncertain malignant potential, malignant) relies on the evaluation of mitotic index, necrosis, and degree of cytologic atypia, with different thresholds based on each subtype. Immunohistochemistry and other ancillary studies may be necessary to establish the diagnosis in a subset of cases, given the morphologic overlap with other mesenchymal neoplasms, including low-grade and high-grade endometrial stromal tumors, inflammatory myofibroblastic tumors, and PEComa. Recent advances in molecular diagnostics have refined the classification of smooth muscle tumors, but most cases are diagnosed purely on histologic grounds.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.