2 型糖尿病与乳腺癌之间的因果关系：双向双样本孟德尔随机研究。

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-04-19 DOI:10.2217/fon-2023-0708

Lihan Zhang, Shuochuan Liu, Guangxing Yue, Hong Niu, Mengjin Hu, Yuling Zheng, Jingwen Tang

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引用次数: 0

摘要

目的观察性研究表明，2 型糖尿病会增加罹患乳腺癌的风险，反之亦然。然而，目前还不能确定这种联系是因果关系还是仅仅由于混杂因素所致。我们采用双向孟德尔随机分析法，从遗传层面评估了这种双向因果关系。研究方法大型全基因组关联研究提供了 2 型糖尿病和乳腺癌的汇总数据。结果遗传预测的 2 型糖尿病与总体乳腺癌或其亚型没有显著的统计学关联。同样，基因预测的总体乳腺癌或其亚型对 2 型糖尿病也没有因果关系。敏感性分析也得出了类似的结果。结论我们的双向孟德尔随机研究表明，2 型糖尿病与乳腺癌之间没有因果关系。

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The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study.

Objective: Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and vice versa. However, it is uncertain whether the link is causal or just due to confounding factors. Using bidirectional Mendelian randomization analysis, we assessed the bidirectional causal relationship from a genetic level. Methods: Large genome-wide association studies yielded summary-level data for Type 2 diabetes and breast cancer. Results: Genetically predicted Type 2 diabetes presented no statistically significant association with overall breast cancer or its subtypes. Similarly, genetically predicted overall breast cancer or its subtypes had no causal effect on Type 2 diabetes. Sensitivity analyses yielded similar results. Conclusion: Our bidirectional Mendelian randomization studies revealed no causal links between Type 2 diabetes and breast cancer.

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico