Alexandra F. Bonthrone, Vanessa Kyriakopoulou, Luke Mason, Andrew Chew, Shona Falconer, Christopher J. Kelly, John Simpson, Kuberan Pushparajah, Mark H. Johnson, A. David Edwards, Chiara Nosarti, Emily J. H. Jones, Serena J. Counsell
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Our aim was to characterise visual attention in toddlers with CHD compared to controls and identify associations with parent-rated effortful control.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Thirty toddlers with CHD (19 male, median (IQR) age at assessment 22.2 (22–23.1) months) and 66 controls from the developing human connectome project (36 male, age at assessment 22 (21.5–23.8) months) using eye-tracking tasks designed to assess multiple components of visual attention. Analyses of co-variance and regressions were used to identify differences between groups and relationships between gaze behaviours and parent-rated effortful control.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Toddlers with CHD were less accurate when switching behaviours (set-shifting) [median (IQR) 79%, (28–100)] compared to controls [100% (86–100), pFDR = 0.032], with worse accuracy associated with lower parent-rated effortful control in CHD but not controls (interaction pFDR = 0.028). Reaction times were slower during selective [CHD 1243 ms (986–1786), controls 1065 ms (0851–1397), pFDR<0.001] and exogenous attention tasks [CHD 312 ms (279–358), control 289 (249–331), (pFDR = 0.032) and endogenous attention was less mature (prolonged looks at facial stimuli CHD 670 ms (518–885), control 500 ms (250–625), (pFDR = 0.006). These results were unrelated to differences in cognition or socioeconomic status. In contrast, the allocation of attentional resources was preserved in CHD.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>We identified a profile of altered attention and early executive functioning development in CHD. Eye-tracking may provide clinically feasible, early objective measures of attention and executive function development in CHD.</p>\n </section>\n </div>","PeriodicalId":73542,"journal":{"name":"JCPP advances","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcv2.12232","citationCount":"0","resultStr":"{\"title\":\"Attentional development is altered in toddlers with congenital heart disease\",\"authors\":\"Alexandra F. Bonthrone, Vanessa Kyriakopoulou, Luke Mason, Andrew Chew, Shona Falconer, Christopher J. Kelly, John Simpson, Kuberan Pushparajah, Mark H. Johnson, A. 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Our aim was to characterise visual attention in toddlers with CHD compared to controls and identify associations with parent-rated effortful control.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Thirty toddlers with CHD (19 male, median (IQR) age at assessment 22.2 (22–23.1) months) and 66 controls from the developing human connectome project (36 male, age at assessment 22 (21.5–23.8) months) using eye-tracking tasks designed to assess multiple components of visual attention. 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引用次数: 0
摘要
先天性心脏病（CHD）是最常见的先天性畸形。存活率超过 90%，但患有先天性心脏病的婴儿仍然很有可能出现注意力和执行功能障碍。这些能力在幼儿期很难评估，因为临床评估依赖于语言能力，而CHD患者的语言能力通常会延迟。我们的目的是通过眼动跟踪任务评估患有先天性心脏病的30名幼儿（19名男性，评估时的年龄中位数（IQR）为22.2（22-23.1）个月）和66名对照组幼儿（36名男性，评估时的年龄为22（21.5-23.8）个月）的视觉注意力。与对照组相比[100% (86-100)，pFDR = 0.032]，患有CHD的幼儿在转换行为（集合转换）时的准确性较低[中位数（IQR）79%，(28-100)]，准确性较低与家长对CHD幼儿的努力控制评分较低有关，但与对照组无关（交互作用pFDR = 0.028）。在选择性任务[CHD 1243 ms (986-1786)，对照组 1065 ms (0851-1397)，pFDR<0.001]和外源性注意任务[CHD 312 ms (279-358)，对照组 289 (249-331)，（pFDR = 0.032）]中，反应时间较慢，内源性注意不太成熟（长时间注视面部刺激，CHD 670 ms (518-885)，对照组 500 ms (250-625)，（pFDR = 0.006）。这些结果与认知或社会经济地位的差异无关。相比之下，注意力资源的分配在CHD患者中得到了保留。眼动追踪可提供临床上可行的早期客观测量方法，以了解CHD患者的注意力和执行功能发展情况。
Attentional development is altered in toddlers with congenital heart disease
Background
Congenital Heart Disease (CHD) is the most common congenital abnormality. Survival rates are over 90%, however infants with CHD remain at high risk of attention and executive function impairments. These abilities are difficult to assess in toddlers because clinical assessments rely on language abilities which are commonly delayed in CHD. Our aim was to characterise visual attention in toddlers with CHD compared to controls and identify associations with parent-rated effortful control.
Methods
Thirty toddlers with CHD (19 male, median (IQR) age at assessment 22.2 (22–23.1) months) and 66 controls from the developing human connectome project (36 male, age at assessment 22 (21.5–23.8) months) using eye-tracking tasks designed to assess multiple components of visual attention. Analyses of co-variance and regressions were used to identify differences between groups and relationships between gaze behaviours and parent-rated effortful control.
Results
Toddlers with CHD were less accurate when switching behaviours (set-shifting) [median (IQR) 79%, (28–100)] compared to controls [100% (86–100), pFDR = 0.032], with worse accuracy associated with lower parent-rated effortful control in CHD but not controls (interaction pFDR = 0.028). Reaction times were slower during selective [CHD 1243 ms (986–1786), controls 1065 ms (0851–1397), pFDR<0.001] and exogenous attention tasks [CHD 312 ms (279–358), control 289 (249–331), (pFDR = 0.032) and endogenous attention was less mature (prolonged looks at facial stimuli CHD 670 ms (518–885), control 500 ms (250–625), (pFDR = 0.006). These results were unrelated to differences in cognition or socioeconomic status. In contrast, the allocation of attentional resources was preserved in CHD.
Conclusions
We identified a profile of altered attention and early executive functioning development in CHD. Eye-tracking may provide clinically feasible, early objective measures of attention and executive function development in CHD.
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