卟啉过度驱动重塑癌细胞新陈代谢

IF 3.3 2区生物学 Q1 BIOLOGY

Life Science Alliance Pub Date : 2024-04-22 DOI:10.26508/lsa.202302547

S. Adapa, Gregory A. Hunter, Narmin E. Amin, Christopher Marinescu, Andrew Borsky, Elizabeth M Sagatys, Said M. Sebti, Gary W. Reuther, Gloria C Ferreira, R. H. Jiang

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引用次数: 0

摘要

癌细胞表现出一种被称为 "卟啉超速 "的代谢表型，其特点是中间体积累的血红素代谢途径失调。这种重新布线是癌症所必需的，也是癌症所特有的。利用 "诱杀 "策略瞄准这一弱点，有望根除恶性细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Porphyrin overdrive rewires cancer cell metabolism

Cancer cells exhibit a metabolic phenotype termed “porphyrin overdrive,” characterized by dysregulated heme metabolic pathways for intermediate accumulation. This rewiring is cancer-essential and cancer-specific. Targeting this vulnerability with a “bait-and-kill” strategy shows promise in eradicating malignant cells.

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来源期刊

Life Science Alliance Agricultural and Biological Sciences-Plant Science

CiteScore

5.80

自引率

2.30%

发文量

241

审稿时长

10 weeks

期刊介绍： Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.