肺腺癌 EBUS FNA 中甲状腺转录因子 1 表达缺失的病例报告。

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2024-04-23 DOI:10.1002/dc.25333

Hitesh Mathew MSc(LSE), MSt(Cantab), FRCPath, Ros Bartle-Jones MBBS(Lond)

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引用次数: 0

摘要

我们报告了一例经组织学确诊为 KRAS 突变、甲状腺转录因子 1 (TTF1) 阳性、1 级黏液腺癌的 76 岁男性病例，该病例的淋巴结转移在细胞学上很难解释，显示出 TTF1 表达缺失以及与鹅口疮细胞增生重叠的特征。该病例凸显了分子检测在非小细胞肺癌（NSCLC）诊断和指导治疗中的重要性。

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A case report of loss of thyroid transcription factor 1 expression in lung adenocarcinoma EBUS FNA

We present a case report of a 76-year-old male with a histologically confirmed KRAS mutated, thyroid transcription factor 1 (TTF1) positive, grade 1, mucinous adenocarcinoma with cytologically difficult to interpret lymph node metastasis showing loss of TTF1 expression and overlapping features with goblet cell hyperplasia. The case highlights the importance of molecular testing in aiding diagnosis and guiding treatment of non-small cell lung carcinomas (NSCLC).

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.