嗅神经室管膜瘤：一个病例系列，以风险因素、病因、临床表现和治疗为重点的系统性文献综述

IF 1.4 4区医学 Q4 ONCOLOGY

Oncologie Pub Date : 2024-04-24 DOI:10.1515/oncologie-2023-0586

Nazmin Ahmed, G. Scalia, G. Umana, Sruthi Ranganathan, Samsul Arifin, Md. Isma Azam, Mohammad Morshad Alam, M. A. Azab, Minaam Farooq, Daniel Encarnación-Santos, Bashir Ahammed, O. Atallah, Bipin Chaurasia

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引用次数: 0

摘要

嗅神经束瘤（ONS）影响负责嗅觉的颅神经 I（CN I）。本系统性综述旨在通过分析 1978 年至 2022 年间发表的 44 篇病例报告/系列文章，全面研究嗅神经束瘤的风险因素、病因、临床表现和治疗方法。我们的系统性综述采用了全面的检索策略，于 2023 年 3 月在多个科学数据库中进行了检索，包括 PubMed、Scopus 和 Web of Science。纳入和排除标准包括人口统计学（即年龄）、临床表现、综合征、受累部位和切除范围等最低限度的信息。所选文章均为病例报告，因此不存在偏倚问题。我们对文章中的上述信息进行了仔细审核，并进行了定性和定量分析。本研究共纳入 44 篇病例报告/系列文章，包括 45 名患者（平均值：38.45）。前颅窝是最常受累的部位（48%）。最常见的手术方法是双额叶开颅手术（16 例），其次是左额叶开颅手术（7 例）。约95.5%的患者接受了全切术（GTR），4.5%的患者接受了次全切术（STR）。两名患者接受了放射治疗。患者的嗅觉功能各不相同，35.5%的患者保留了嗅觉功能，28.88%的患者的嗅觉功能受损或丧失。约 66.6% 的病例取得了积极的疗效，15% 的病例出现了并发症，包括脑脊液（CSF）鼻出血和复视。对患者进行长期随访和定期筛查势在必行。进一步的研究对于阐明ONS的确切发病机制和开发更好的治疗方法至关重要。本综述全面概述了有关鼻咽癌的知识现状；然而，由于该病非常罕见，只有病例报告作为主要研究，因此很难得出有力的结论。

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Olfactory Nerve Schwannoma: a case series with a systematic review of the literature focusing risk factors, etiology, clinical presentation, and management

Olfactory Nerve Schwannomas (ONS) affect cranial nerve I (CN I), responsible for the sense of smell. This systematic review aims to comprehensively examine the risk factors, etiology, clinical presentation, and management of ONS by analyzing 44 case reports/series published from 1978 to 2022. Our systematic review utilized a comprehensive search strategy across various scientific databases, including PubMed, Scopus, and Web of Science in March 2023. The inclusion and exclusion criteria included minimum information on demographics (i.e., age), clinical presentation, syndrome, area involved, and extent of resection. The selected articles were case reports, so there is no question about bias. Articles were meticulously reviewed for the above information and underwent both qualitative and quantitative analysis. A total of 44 case reports/series, consisting of 45 patients, were included in this study (mean: 38.45). The anterior cranial fossa was the most frequently involved area (48 %). The most common surgical procedure was bifrontal craniotomy (n=16), followed by left frontal craniotomy (n=7). Approximately 95.5 % of patients underwent Gross Total Resection (GTR), while 4.5 % had Subtotal Resection (STR). Radiotherapy was applied to two patients. Olfactory function varied, with 35.5 % preserving it and 28.88 % experiencing damage or loss. Positive outcomes were observed in approximately 66.6 % of cases, with complications reported in 15 % of instances, including cerebrospinal fluid (CSF) rhinorrhea and diplopia. Long-term follow-up and regular screening of patients are imperative. Further research is essential to elucidate the precise pathogenesis and to develop improved treatment modalities for ONS. This review provides a comprehensive overview of the current state of knowledge regarding ONS; however, as the disease is very rare, only case reports are available as a primary study, making it difficult to reach a strong conclusion.

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来源期刊

Oncologie 医学-肿瘤学

CiteScore

1.30

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.