预测单侧多灶性甲状腺乳头状癌患者中央淋巴结转移的超声和临床因素。

IF 1.4 4区 医学 Q4 ONCOLOGY
Zhenwei Liang, Jixin Zhang, Lei Chen, Jinghua Liu, Fumin Wang, Yuhong Shao, Xiu-yun Sun, Luzeng Chen
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引用次数: 0

摘要

目的这项涉及单侧多灶性甲状腺乳头状癌(UM-PTC)大数据集的回顾性研究旨在确定预测患者中央淋巴结转移(CLNM)的因素。方法我们确定了一组 158 例接受宫颈超声检查并根据术后病理诊断为 UM-PTC 的患者。我们使用单变量和多变量分析评估了 CLNM 与 UM-PTC 临床超声特征之间的关系。结果在158例UM-PTC患者中,CLNM的发生率为29.7%(47/158)。单变量和多变量分析显示,声像图特征相似度(NSSF)≥4(比值比 [OR] = 11.335,95% 置信区间 [CI]:3.95-32.50,P = 0.000)、微钙化(OR = 3.54,95% CI:1.30-9.70,P = 0.014)、TTD ≥2 cm(OR = 4.48,95% CI:1.62-12.34,P = 0.004)、结节数≥3(OR = 13.17,95% CI:3.24-53.52,p = 0.000)和侧颈淋巴结转移(LLNM)(OR = 5.57,95% CI:1.59-19.48,p = 0.007)与 UM-PTC 的 CLNM 独立相关。ROC 曲线分析显示,TTD 临界值为 1.795 厘米时,预测 CLNM 的灵敏度为 0.723,特异度为 0.676。NSSF≥4、微钙化、TTD≥2 cm、LLNM和结节数≥3与CLNM独立相关。我们的数据表明,超声可指导 UM-PTC 治疗中的手术决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrasound and clinical factors predicting central lymph node metastases in patients with unilateral multifocal papillary thyroid carcinoma.
OBJECTIVE This retrospective study involving a large dataset of unilateral multifocal papillary thyroid carcinoma (UM-PTC) sought to identify factors that predict central lymph node metastases (CLNM) in patients. METHODS We identified a cohort of 158 patients who underwent cervical ultrasonography followed by UM-PTC diagnosis based on postoperative pathology. The relationship between CLNM and UM-PTC clinical ultrasound features was evaluated using univariate and multivariate analyses. Receiver operating characteristic (ROC) curve analysis was used to determine the ability of total tumor diameter (TTD) to predict CLNM. RESULTS Among the 158 UM-PTC patients, the incidence of CLNM was 29.7% (47/158). Univariate and multivariate analyses revealed that a number of similarity of sonographic features (NSSF) ≥4 (odds ratio [OR] = 11.335, 95% confidence interval [CI]: 3.95-32.50, p = 0.000), microcalcifications (OR = 3.54, 95% CI: 1.30-9.70, p = 0.014), a TTD of ≥2 cm (OR = 4.48, 95% CI: 1.62-12.34, p = 0.004), number of nodules ≥3 (OR = 13.17, 95% CI: 3.24-53.52, p = 0.000), and Lateral cervical lymph node metastasis (LLNM) (OR = 5.57, 95% CI: 1.59-19.48, p = 0.007) were independently associated with CLNM in UM-PTC. ROC curve analysis revealed that the TTD cut-off of 1.795 cm had a sensitivity of 0.723 and a specificity of 0.676 for predicting CLNM. CONCLUSIONS Patients with UM-PTC are at high risk of CLNM. NSSF ≥4, microcalcifications, TTD of ≥2 cm, LLNM, and a number of nodules ≥3 were independently associated with CLNM. Our data show that ultrasound may guide surgical decisions in the treatment of UM-PTC.
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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
175
审稿时长
6-12 weeks
期刊介绍: Asia–Pacific Journal of Clinical Oncology is a multidisciplinary journal of oncology that aims to be a forum for facilitating collaboration and exchanging information on what is happening in different countries of the Asia–Pacific region in relation to cancer treatment and care. The Journal is ideally positioned to receive publications that deal with diversity in cancer behavior, management and outcome related to ethnic, cultural, economic and other differences between populations. In addition to original articles, the Journal publishes reviews, editorials, letters to the Editor and short communications. Case reports are generally not considered for publication, only exceptional papers in which Editors find extraordinary oncological value may be considered for review. The Journal encourages clinical studies, particularly prospectively designed clinical trials.
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