实现更绿色、更具成本效益的药物和香料分子的生物合成

IF 1.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chimia Pub Date : 2024-04-24 DOI:10.2533/chimia.2024.222

Ana I. Benítez Mateos

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引用次数: 0

摘要

酶是天然催化剂，由于其外选性和生物可降解性，在化学合成中的应用越来越广泛。然而，要完全释放酶在工业应用中的潜力，必须提高整个生物催化过程的成本效益和可持续性。为了实现这一目标，酶的固定化和与连续流反应器的整合一直是我们研究的基石。我们展示了这些工具在生物合成抗病毒药物、抗癌药物和有价值的香料分子方面的优势。通过将固定生物催化剂的新策略、创新的生物工程方法和工艺开发相结合，反应的性能可提高 100 倍。

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Towards Greener and More Cost-efficient Biosynthesis of Pharmaceuticals and Fragrance Molecules

Enzymes are natural catalysts which are gaining momentum in chemical synthesis due to their exquisiteselectivity and their biodegradability. However, the cost-efficiency and the sustainability of the overall biocatalytic process must be enhanced to unlock completely the potential of enzymes for industrial applications. To reach this goal, enzyme immobilization and the integration into continuous flow reactors have been the cornerstone of our research. We showed key examples of the advantages of those tools for the biosynthesis of antivirals, anticancer drugs, and valuable fragrance molecules. By combining new strategies to immobilize biocatalysts, innovative bioengineering approaches, and process development, the performance of the reactions could be boosted up to 100-fold.

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来源期刊

Chimia 化学-化学综合

CiteScore

1.60

自引率

0.00%

发文量

144

审稿时长

2 months

期刊介绍： CHIMIA, a scientific journal for chemistry in the broadest sense covers the interests of a wide and diverse readership. Contributions from all fields of chemistry and related areas are considered for publication in the form of Review Articles and Notes. A characteristic feature of CHIMIA are the thematic issues, each devoted to an area of great current significance.