二乙酰姜黄素：根管消毒中对抗粪肠球菌生物膜的新策略。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-04-25 DOI:10.2217/fmb-2023-0235

Vanessa de Souza, C. Polaquini, Graciele Ribeiro de Moraes, Arthur Rodrigues Oliveira Braga, Priscila Vieira da Silva, Diego Romário da Silva, Francisco Ricardo Ribeiro Lima, L. Regasini, Janaina de Cássia Orlandi Sardi

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引用次数: 0

摘要

目的：我们评估了姜黄素的衍生物二乙酰姜黄素（DAC）对粪肠球菌的抗菌和抗生物膜特性。研究方法测定了DAC的最低抑菌浓度（MIC）和最低杀菌浓度、抗生物膜潜能和毒性。此外，还进行了硅计算分析，以了解其作用机制。结果与结论DAC 具有明显的抗菌效果，MIC 和 MBC 值分别为 15.6 和 31.25 μg/ml，并能减少生物膜的形成。如果与氢氧化钙一起使用，还能产生协同效应，使生物膜减少 77%。对ellonella 的毒性测试证实了 DAC 在测试浓度下的安全性，这表明它有潜力用于根管消毒产品。

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Diacetylcurcumin: a novel strategy against Enterococcus faecalis biofilm in root canal disinfection.

Aim: We evaluated Diacetylcurcumin (DAC), a derivative of curcumin, for its antibacterial and antibiofilm properties against Enterococcus faecalis. Methods: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration were determined, along with antibiofilm potential and toxicity in Galleria mellonella. Additionally, in silico computational analysis was performed to understand its mechanisms of action. Results & conclusion: DAC demonstrated significant antibacterial effects, with MIC and MBC values of 15.6 and 31.25 μg/ml, respectively, and reduced biofilm formation. A synergistic effect, reducing biofilm by 77%, was observed when combined with calcium hydroxide. G. mellonella toxicity tests confirmed DAC's safety at tested concentrations, suggesting its potential for use in root canal disinfection products.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.