利用肿瘤微环境提高疗效

IF 72.5 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2024-04-26 DOI:10.1038/s41568-024-00693-8

Zuzana Tatarova

引用次数: 0

摘要

靶向抗癌药和化疗利用了癌细胞的内在弱点。然而，有证据表明，局部肿瘤微环境（TME）可影响肿瘤行为，从而促进或抑制肿瘤生长。针对肿瘤细胞弱点的药物也会影响肿瘤微环境。了解了这些影响，就能开发出既能直接抑制癌细胞，又能对肿瘤微环境产生间接抗癌作用的药物组合。我们开发了多重植入式微装置检测法（MIMA），这是一个综合分析平台，可提供有效治疗设计所需的癌症和TME药物反应定量信息。MIMA 系统可以评估动物模型和人体对药物和药物组合的反应；使用微型植入式微装置进行局部但空间上独立的纳升级药物瘤内给药；使用 30 多种蛋白质的多重免疫染色和定量成像来确定癌症组织中的癌细胞、免疫细胞和基质细胞的类型、分子状态和组织。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Using the tumour microenvironment to improve therapy efficacy

In this Tools of the Trade article, Zuzana Tatarova describes the development of MIMA, an integrated analytical platform providing the quantitative information on tumour microenvironment drug responses required for effective treatment design.

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.