针对 APOC3 的 RNA 型疗法可降低高甘油三酯血症患者的甘油三酯水平

IF 41.7 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2024-04-23 DOI:10.1038/s41569-024-01034-w

Karina Huynh

引用次数: 0

摘要

在 ACC.24 上公布的三项随机临床试验表明，针对 APOC3 的 RNA 型疗法 olezarsen 和 plozasiran 可以有效降低中度至重度高甘油三酯血症患者的血浆甘油三酯水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia

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RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia

Three randomized clinical trials presented at ACC.24 demonstrate that olezarsen and plozasiran, RNA-based therapies that target APOC3, can robustly reduce plasma triglyceride levels in patients with moderate to severe hypertriglyceridaemia.

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.