登革热病毒发病机制和宿主分子机制

IF 9 2区 医学 Q1 CELL BIOLOGY
Saumya Sinha, Kinjal Singh, Y. S. Ravi Kumar, Riya Roy, Sushant Phadnis, Varsha Meena, Sankar Bhattacharyya, Bhupendra Verma
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引用次数: 0

摘要

登革病毒(DENV)是属于黄病毒科的正链 RNA 病毒。DENV 是登革热的病原体,登革热是由蚊子传播最迅速的病毒性疾病。每年都有数百万人因被伊蚊类受感染的雌蚊叮咬而感染该病毒。大多数人感染登革热后没有症状,免疫系统会在几天内成功控制病毒复制。无症状者可能会出现轻度发烧(登革热或 DF),可能会也可能不会发展成更严重的疾病,即登革出血热(DHF)或致命的登革休克综合征(DSS)。由于缺乏普遍接受的预防性疫苗或治疗药物,治疗主要限于支持性措施。与其他许多诱发急性疾病的病毒类似,登革热病毒已开发出多种调节宿主新陈代谢的方法,以创造有利于基因组复制和病毒后代传播的环境。要寻找新的治疗方案,就必须了解病毒生命周期中各种生物过程所涉及的宿主-病毒调控系统。本综述旨在总结 DENV 与宿主细胞机制之间复杂的相互作用,包括不同分子水平的调控机制,如宿主基因组的表观遗传调控、宿主基因的转录、病毒和宿主 mRNA 的翻译、宿主转录组的转录后调控、病毒蛋白的翻译后调控以及参与蛋白降解的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dengue virus pathogenesis and host molecular machineries
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species. In the majority of individuals, the infection is asymptomatic, and the immune system successfully manages to control virus replication within a few days. Symptomatic individuals may present with a mild fever (Dengue fever or DF) that may or may not progress to a more critical disease termed Dengue hemorrhagic fever (DHF) or the fatal Dengue shock syndrome (DSS). In the absence of a universally accepted prophylactic vaccine or therapeutic drug, treatment is mostly restricted to supportive measures. Similar to many other viruses that induce acute illness, DENV has developed several ways to modulate host metabolism to create an environment conducive to genome replication and the dissemination of viral progeny. To search for new therapeutic options, understanding the underlying host-virus regulatory system involved in various biological processes of the viral life cycle is essential. This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-translational regulation of viral proteins, and pathways involved in protein degradation.
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来源期刊
Journal of Biomedical Science
Journal of Biomedical Science 医学-医学:研究与实验
CiteScore
18.50
自引率
0.90%
发文量
95
审稿时长
1 months
期刊介绍: The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.
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